Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …

The Notch signalling pathway is evolutionarily conserved and is crucial for the development
and homeostasis of most tissues. Deregulated Notch signalling leads to various diseases …

Cells acquire their ultimate identities by activating combinations of transcription factors that
initiate and sustain expression of the appropriate cell type-specific genes. T cell …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

The generation of a functional and diverse repertoire of T cells occurs in the thymus from
precursors arriving from the bone marrow. In this article, we introduce the various stages of …

T cells are the key mediators in cell-mediated immunity. Their development and maturation
involve a complex variety of interactions with nonlymphoid cell products and receptors …

Many advances in our understanding of the molecules that regulate the development,
differentiation and function of T cells have been made over the past few years. One …

Abstract O-linked-N-acetylglucosaminylation (O-GlcNAcylation) is a type of glycosylation that
occurs when a monosaccharide, O-GlcNAc, is added onto serine or threonine residues of …

The differentiation of αβT cells from thymic precursors is a complex process essential for
adaptive immunity. Here we exploited the breadth of expression data sets from the …

Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation
process in which they gradually acquire T-cell characteristics while shedding their legacy of …