This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Regulated exocytosis is the main mechanism utilized by specialized secretory cells to
deliver molecules to the cell surface by virtue of membranous containers (ie, secretory …

Protein secretion from acinar cells of the pancreas and parotid glands is controlled by G-
protein coupled receptor activation and generation of the cellular messengers Ca 2+ …

Mutations in TRPML 1 cause the lysosomal storage disease mucolipidosis type IV (MLIV).
The role of TRPML 1 in cell function and how the mutations cause the disease are not well …

The role of Beta-adrenergic receptors (B-ARs) remains controversial in normal and tumor
breast. Herein we explore the cAMP signaling involved in B-AR-dependent control of …

Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very
diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its …

The acrosome reaction is the regulated exocytosis of mammalian sperm's single secretory
granule, essential for fertilization. It relies on small GTPases, the cAMP binding protein Epac …

Phospholamban (PLN) is an important Ca2+ modulator at the sarcoplasmic reticulum (SR)
of striated muscles. It physically interacts and inhibits sarcoplasmic reticulum Ca2+ ATP ase …

Abstract OBJECTIVE: Kinase Anchoring Proteins (AKAPs) have evolved to regulate the
spatial and temporal organization of cellular signal transduction. As a typical member …

ABSTRACT A-kinase anchoring protein 79/150 (AKAP79/150) is an important scaffolding
protein, which anchors various important proteins to locate in appropriate synaptic domains …