The neuropsychiatry of Parkinson's disease: advances and challenges

D Weintraub, D Aarsland, KR Chaudhuri… - The Lancet …, 2022 - thelancet.com
In people with Parkinson's disease, neuropsychiatric signs and symptoms are common
throughout the disease course. These symptoms can be disabling and as clinically relevant …

[HTML][HTML] Depression in patients with Parkinson's disease: current understanding of its neurobiology and implications for treatment

S Prange, H Klinger, C Laurencin, T Danaila… - Drugs & Aging, 2022 - Springer
Depression is one of the most frequent and burdensome non-motor symptoms in
Parkinson's disease (PD), across all stages. Even when its severity is mild, PD depression …

Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy

P Krack, J Volkmann, G Tinkhauser… - Movement …, 2019 - Wiley Online Library
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …

Cellular, molecular, and clinical mechanisms of action of deep brain stimulation—a systematic review on established indications and outlook on future developments

M Jakobs, A Fomenko, AM Lozano… - EMBO molecular …, 2019 - embopress.org
Deep brain stimulation (DBS) has been successfully used to treat movement disorders, such
as Parkinson's disease, for more than 25 years and heralded the advent of electrical …

How does deep brain stimulation change the course of Parkinson's disease?

P Mahlknecht, T Foltynie, P Limousin… - Movement …, 2022 - Wiley Online Library
A robust body of evidence from randomized controlled trials has established the efficacy of
deep brain stimulation (DBS) in reducing off time and dyskinesias in levodopa‐treated …

Biomarkers for closed-loop deep brain stimulation in Parkinson disease and beyond

W Bouthour, P Mégevand, J Donoghue… - Nature Reviews …, 2019 - nature.com
Subthalamic deep brain stimulation (DBS) for Parkinson disease (PD) currently requires
laborious open-loop programming, which can mitigate the benefits of this treatment …

An update on best practice of deep brain stimulation in Parkinson's disease

CJ Hartmann, S Fliegen, SJ Groiss… - Therapeutic …, 2019 - journals.sagepub.com
During the last 30 years, deep brain stimulation (DBS) has evolved into the clinical standard
of care as a highly effective treatment for advanced Parkinson's disease. Careful patient …

The neuropsychiatry of Parkinson disease: a perfect storm

D Weintraub, E Mamikonyan - The American Journal of Geriatric Psychiatry, 2019 - Elsevier
Affective disorders, cognitive decline, and psychosis have long been recognized as common
in Parkinson disease (PD), and other psychiatric disorders include impulse control …

[HTML][HTML] Deep brain stimulation selection criteria for Parkinson's disease: time to go beyond CAPSIT-PD

CA Artusi, L Lopiano, F Morgante - Journal of clinical medicine, 2020 - mdpi.com
Despite being introduced in clinical practice more than 20 years ago, selection criteria for
deep brain stimulation (DBS) in Parkinson's disease (PD) rely on a document published in …

Apathy induced by subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta‐analysis

TJC Zoon, G van Rooijen, GMFC Balm… - Movement …, 2021 - Wiley Online Library
Apathy, the loss of motivation, is a common problem in Parkinson's disease (PD) and often
observed following deep brain stimulation (DBS) of the subthalamic nucleus (STN). The aim …