In this paper, we survey the main superstructure-based approaches in process system
engineering, with a particular emphasis on the existing literature for automated …

Real-time release testing (RTRt) of tablet dissolution can significantly improve
manufacturing efficiency along with the adoption of continuous manufacturing in the …

This paper presents surrogate models of dissolution behavior to identify the critical input
parameters in tablet manufacturing processes. Dissolution behavior is a critical quality …

The global pharmaceutical industry is a trillion‐dollar market. However, the pharmaceutical
sector often lags in manufacturing innovation and automation which limits its potential to …

This work presents a granule size prediction approach applicable to diverse formulations
containing new active pharmaceutical ingredients (APIs) in continuous twin-screw wet …

This paper presents an application case of model-based design of experiments for the
continuous twin-screw wet granulation and fluid-bed drying sequence. The proposed …

Toward further implementation of continuous tablet manufacturing, one key issue is the time
needed for start-up operation because it could lead to lower product yield and reduced …

We presented a control strategy for tablet manufacturing processes based on continuous
direct compression. The work was conducted by the experts of pharmaceutical companies …

The pharmaceutical industry has shown a strong interest in flow synthesis and continuous
production. In general, solvent selection is performed based on solubility and …

This work presents a model-based comparison of the batch and flow syntheses for
doripenem, which is an antibiotic active pharmaceutical ingredient. The targeted reaction is …