Hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery

JP Thaler, DE Cummings - Endocrinology, 2009 - academic.oup.com
Bariatric surgery is the most effective available treatment for obesity. The most frequently
performed operation, Roux-en-Y gastric bypass (RYGB), causes profound weight loss and …

Metabolic surgery to treat type 2 diabetes: clinical outcomes and mechanisms of action

F Rubino, PR Schauer, LM Kaplan… - Annual review of …, 2010 - annualreviews.org
Several gastrointestinal (GI) operations that were designed to promote weight loss can
powerfully ameliorate type 2 diabetes mellitus (T2DM). Although T2DM is traditionally …

Improvement in glucose metabolism after bariatric surgery: comparison of laparoscopic Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: a prospective …

R Peterli, B Wölnerhanssen, T Peters, N Devaux… - 2009 - journals.lww.com
Background: The exclusion of the proximal small intestine is thought to play a major role in
the rapid improvement in the metabolic control of diabetes after gastric bypass. Objective: In …

Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass

C Dirksen, NB Jørgensen, KN Bojsen-Møller… - Diabetologia, 2012 - Springer
Roux-en-Y gastric bypass (RYGB) greatly improves glycaemic control in morbidly obese
patients with type 2 diabetes, in many even before significant weight loss. Understanding the …

A multicenter, randomized efficacy study of the EndoBarrier Gastrointestinal Liner for presurgical weight loss prior to bariatric surgery

R Schouten, CS Rijs, ND Bouvy, W Hameeteman… - 2010 - journals.lww.com
Background: The endoscopically placed duodenal-jejunal bypass sleeve or EndoBarrier
Gastrointestinal Liner has been designed to achieve weight loss in morbidly obese patients …

Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery

DE Cummings - International journal of obesity, 2009 - nature.com
Bariatric surgery is currently the most effective method to promote major, sustained weight
loss. Roux-en-Y gastric bypass (RYGB), the most commonly performed bariatric operation …

Open-label, sham-controlled trial of an endoscopic duodenojejunal bypass liner for preoperative weight loss in bariatric surgery candidates

KS Gersin, RI Rothstein, RJ Rosenthal… - Gastrointestinal …, 2010 - Elsevier
BACKGROUND: The duodenojejunal bypass liner (DJBL)(EndoBarrier Gastrointestinal
Liner) is an endoscopically placed and removable intestinal liner that creates a …

The effect of the endoscopic duodenal-jejunal bypass liner on obesity and type 2 diabetes mellitus, a multicenter randomized controlled trial

P Koehestanie, C de Jonge, FJ Berends, IM Janssen… - 2014 - journals.lww.com
Objective: Investigate the safety and efficacy of 6 months' duodenal-jejunal bypass liner
(DJBL) treatment in comparison with dietary intervention for obesity and type 2 diabetes …

Endoscopic duodenal–jejunal bypass liner rapidly improves type 2 diabetes

C de Jonge, SS Rensen, FJ Verdam, RP Vincent… - Obesity surgery, 2013 - Springer
Background Bariatric procedures excluding the proximal small intestine improve glycemic
control in type 2 diabetes within days. To gain insight into the mediators involved, we …

Effect of the EndoBarrier G astrointestinal L iner on obesity and type 2 diabetes: a systematic review and meta‐analysis

U Rohde, N Hedbäck, LL Gluud… - Diabetes, Obesity and …, 2016 - Wiley Online Library
Compared with bariatric surgery, less invasive and reversible techniques to counteract
obesity and type 2 diabetes (T2D) have been developed, including the EndoBarrier G …