Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …

Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …

Importance The incidence of SARS-CoV-2 infection, including among individuals who have
received 2 doses of COVID-19 vaccine, increased substantially following the emergence of …

The protective efficacy of serum antibodies results from the interplay of antigen-specific B
cell clones of different affinities and specificities. These cellular dynamics underlie serum …

In addition to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), humans are
also susceptible to six other coronaviruses, for which consecutive exposures to antigenically …

The SARS-CoV-2 proteome shares regions of conservation with endemic human
coronaviruses (CoVs), but it remains unknown to what extent these may be cross …

SARS-CoV-2 infection causes diverse outcomes ranging from asymptomatic infection to
respiratory distress and death. A major unresolved question is whether prior immunity to …

To combat the evolving SARS-CoV-2 Omicron variants, bivalent COVID-19 mRNA vaccines,
encoding both ancestral and Omicron BA. 5 spikes, have replaced monovalent vaccines in …

In 2018, the world commemorated the centennial of the 1918 influenza A (H1N1) pandemic,
the deadliest pandemic in recorded history; however, little mention was made of the 50th …

Abstract With declining SARS-CoV-2-specific antibody titers and increasing numbers of
spike mutations, the ongoing emergence of Omicron subvariants causes serious challenges …