Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Host genetics are known to influence the gut microbiome, yet their role remains poorly
understood. To robustly characterize these effects, we performed a genome-wide …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

Diabetes and hypertension frequently occur together. There is substantial overlap between
diabetes and hypertension in etiology and disease mechanisms. Obesity, inflammation …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

Body mass index (BMI), a proxy measure for obesity, is determined by both environmental
(including ethnicity, age, and sex) and genetic factors, with> 400 BMI-associated loci …

Genome-wide association studies (GWAS) have revolutionised the discovery of genes for
common traits and diseases, including obesity-related traits. In less then four years time, 52 …

The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However,
who becomes obese in an obesity-prone environment is largely determined by genetic …

Obesity is a disorder characterized by an excess accumulation of body fat resulting from a
mismatch between energy intake and expenditure. Incidence of obesity has increased …