Dual targeting strategies with bispecific antibodies

R Kontermann - MAbs, 2012 - Taylor & Francis
Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and
infectious diseases and other disorders. Most of the marketed antibodies are monospecific …

Scorpion species of medical importance in the Brazilian Amazon: a review to identify knowledge gaps

JG Martins, GC Santos, REL Procópio… - Journal of Venomous …, 2021 - SciELO Brasil
Scorpionism is a relevant medical condition in Brazil. It is responsible for most accidents
involving venomous animals in the country, which leads to severe symptoms that can evolve …

VHH, bivalent domains and chimeric heavy chain-only antibodies with high neutralizing efficacy for scorpion toxin AahI′

I Hmila, D Saerens, Z Benlasfar, K Conrath… - Molecular …, 2008 - Elsevier
Many efforts aim at solving the serious problems encountered with immunotherapy against
scorpion envenoming. The most attractive approach consists in generating single-chain …

Pathophysiological effects of Androctonus australis hector scorpion venom: tissue damages and inflammatory response

S Adi-Bessalem, D Hammoudi-Triki… - Experimental and …, 2008 - Elsevier
In this study, the effects of sublethal dose of Androctonus australis hector (Aah) venom on
the enzymatic activities (creatine phospho-kinase and lactate dehydrogenase) and …

Snake Antivenoms—Toward Better Understanding of the Administration Route

E Gamulin, S Mateljak Lukačević, B Halassy, T Kurtović - Toxins, 2023 - mdpi.com
Envenomations induced by animal bites and stings constitute a significant public health
burden. Even though a standardized protocol does not exist, parenterally administered …

Identification and Antibody-Therapeutic Targeting of Chloramphenicol-Resistant Outer Membrane Proteins in Escherichia coli

H Li, X Lin, S Wang, X Peng - Journal of Proteome research, 2007 - ACS Publications
Bacterial resistance to an antibiotic may result from survival in a suddenly strong antibiotic or
in sub-minimum inhibitory concentration of the drug. Their shared proteins responsible for …

[HTML][HTML] Neutralization Capacity of Tissue Alterations Caused by the Venoms of the Most Dangerous Scorpions in North Africa Using a Selective Antivenom

B Darkaoui, M Aksim, A Aarab, A Lafnoune… - Toxins, 2023 - mdpi.com
In North Africa, scorpion stings pose an urgent public health problem, particularly for
children with high morbidity and mortality rates. The main species implicated are the …

Epidemiological, clinical, biological and evolutionary profile of scorpion envenomed children under one year to 15 years in the Souss Massa region of Morocco

B Darkaoui, MA El Hidan, A Lafnoune, D Arourd… - Toxicon, 2024 - Elsevier
Morocco is one of the main countries affected in North African with the scorpion
envenomations. Faced with the threat, significant morbidity and a major risk of death …

Development of a new approach of immunotherapy against scorpion envenoming: Avian IgYs an alternative to equine IgGs

A Sifi, S Adi-Bessalem, F Laraba-Djebari - International …, 2018 - Elsevier
Antivenom treatment has been largely used against scorpion stings. Despite their efficacy,
the use of mammalian antivenoms may cause adverse effects due to the immune system …

Pre-clinical studies of toxin-specific Nanobodies: Evidence of in vivo efficacy to prevent fatal disturbances provoked by scorpion envenoming

I Hmila, B Cosyns, H Tounsi, B Roosens… - Toxicology and applied …, 2012 - Elsevier
Scorpions represent a significant threat to humans and animals in various countries
throughout the world. Recently, we introduced Nanobodies (Nbs) to combat more efficiently …