Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone
degeneration, as well as synovitis, are the main pathological changes associated with knee …

Osteoarthritis (OA) has a very high incidence worldwide and has become a very common
joint disease in the elderly. Currently, the treatment methods for OA include surgery, drug …

With a rapid increase in the aging population, osteoporosis has become a global health
problem. Although anti-resorption and anabolic drugs are available, osteoporosis cannot be …

Background: Mechanical loading and alendronate (ALN) can be used as noninvasive
physical therapy methods for osteoarthritis (OA). However, the timing and efficacy for …

Background: Lubricin, or proteoglycan 4 (PRG4), is a glycoprotein responsible for joint
boundary lubrication. PRG4 has been shown previously to be down-regulated after …

Aging induces alterations in bone structure and strength through a multitude of processes,
exacerbating common aging-related diseases like osteoporosis and osteoarthritis. Cellular …

Objective To evaluate the dose–response relationship of exercise loading in the cartilage-
subchondral bone (SB) unit in surgically-induced post-traumatic osteoarthritis (PTOA) of the …

Osteoarthritis (OA) is a disease characterized by non-bacterial inflammation. Histone
deacetylase 3 (HDAC3) is a crucial positive regulator in the inflammation that leads to the …

This study aimed to investigate the additional effect of ovariectomy-induced osteoporosis
(OP) on the pathology of knee osteoarthritis (OA) in a rat meniscectomized model …

For decades, the osteogenic effect from different physical activities on bone in rodents
remained uncertain. This literature review presents for the first time the effects on five …