When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

Proteins tendency to bind to one another in a highly specific manner forming stable
complexes is fundamental to all biological processes. A better understanding of complex …

Protein–protein interactions (PPIs) are important targets for the development of chemical
probes and therapeutic agents. From the initial discovery of the existence of hot spots at PPI …

The unanimous agreement that cellular processes are (largely) governed by interactions
between proteins has led to enormous community efforts culminating in overwhelming …

Protein–protein binding is one of the critical events in biology, and knowledge of proteic
complexes three‐dimensional structures is of fundamental importance for the biochemical …

Connects fundamental knowledge of multivalent interactions with current practice and state-
of-the-art applications Multivalency is a widespread phenomenon, with applications …

Understanding protein–protein association and being able to determine the crucial residues
responsible for their association (hot-spots) is a key issue with huge practical applications …

Protein–protein interactions (PPI) are crucial for the establishment of life. However, its basic
principles are still elusive and the recognition process is yet to be understood. It is important …

Proteins and protein-based complexes are the basis of many key systems in nature and
have been the subject of intense research in the last decades, in an attempt to acquire …

Understanding protein–protein interactions (PPIs) is fundamental to describe and to
characterize the formation of biomolecular assemblies, and to establish the energetic …