Extending therapeutic use of psychostimulants: focus on serotonin-1A receptor

DJ Haleem - Progress in Neuro-Psychopharmacology and …, 2013 - Elsevier
Introduction Despite a number of medicinally important pharmacological effects, the
therapeutic use of psychostimulants is limited because of abuse potential and psychosis …

[PDF][PDF] Repeated treatment with reserpine as a progressive animal model of depression.

H Ikram, DJ Haleem - Pakistan Journal of Pharmaceutical …, 2017 - researchgate.net
Treatment-resistant depression is a major health problem worldwide. Restricted validity of
the existing animal models of depression along with the need for the study of progressive …

The effects of early-life stress on dopamine system function in adolescent female rats

I Majcher-Maślanka, A Solarz, K Wędzony… - International Journal of …, 2017 - Elsevier
During adolescence, many neural systems, including the dopamine system, undergo
essential remodeling and maturation. It is well known that early-life stress (ELS) increases …

Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's dementia.

H Ikram, DJ Haleem - Pakistan Journal of Pharmaceutical …, 2019 - search.ebscohost.com
Present study was designed to monitor the cognitive profile of the animals upon repeated
administration of reserpine, so as to determine that whether these animals should be used …

[HTML][HTML] Anxiolytic profile of fluoxetine as monitored following repeated administration in animal rat model of chronic mild stress

M Farhan, DJ Haleem - Saudi Pharmaceutical Journal, 2016 - Elsevier
Background: Fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), has been proposed
to be more effective as an antidepressive drug as compared to other SSRIs. After chronic …

Neurochemical and behavioral effects of Nigella sativa and Olea europaea oil in rats

MAR Cheema, S Nawaz, S Gul, T Salman… - Nutritional …, 2018 - Taylor & Francis
Objectives: In the last few decades, therapeutic uses of medicinal compounds present in
food as a normal constituent has risen substantially, largely because of their fewer side …

Effects of sugar rich diet on brain serotonin, hyperphagia and anxiety in animal model of both genders.

QA Inam, H Ikram, E Shireen… - Pakistan journal of …, 2016 - search.ebscohost.com
Abstract Lower levels of 5-hydroxytryptamine (5-HT; serotonin) in the brain elicit sugar
craving, while ingestion of sugar rich diet improves mood and alleviates anxiety. Gender …

[PDF][PDF] Unpredictable chronic mild stress induced behavioral deficits: a comparative study in male and female rats.

M Farhan, H Ikram, S Kanwal… - Pakistan Journal of …, 2014 - academia.edu
Stress is an important precipitant factor for depression. Changes in various body systems
that occur in depression are similar to those observed in response to stress. Chronic stress …

[PDF][PDF] Neurochemical and behavioral effects of green tea (Camellia sinensis): a model study

B Mirza, H Ikram, S Bilgrami, DJ Haleem… - Pak. J. Pharm …, 2013 - researchgate.net
Being rich in polyphenolic compounds such as flavonoids, green tea is suggested to be a
potential candidate for the treatment of obesity, stress, depression, Parkinson's and other …

The dopaminergic D1 receptor modulates the hyperactivity of Bapa mutant mice

MA de Oliveira-Higa, P da Silva Rodrigues… - Behavioural Brain …, 2023 - Elsevier
The mutant bate-palmas (“claps”; symbol-bapa) mice induced by the mutagenic chemical
ENU present motor incoordination and postural alterations. A previous study showed that …