Vertebrate vision critically depends on an 11-cis-retinoid renewal system known as the
visual cycle. At the heart of this metabolic pathway is an enzyme known as retinal pigment …

The retinal pigment epithelium-photoreceptor interphase is renewed each day in a stunning
display of cellular interdependence. While photoreceptors use photosensitive pigments to …

G protein-coupled receptors (GPCRs) are cell-surface receptors that respond to various
stimuli to induce signalling pathways across cell membranes. Recent progress has yielded …

ABCA4 is a member of the superfamily of ATP-binding cassette (ABC) transporters that is
preferentially localized along the rim region of rod and cone photoreceptor outer segment …

The number of double bonds in the acyl chains of membrane lipids varies tremendously at
all scales of life, from the organism level to the subcellular level, where differences in lipid …

The fatty acid composition of photoreceptor outer segment (POS) phospholipids diverges
from other membranes, being highly enriched in polyunsaturated fatty acids (PUFAs). The …

Atomic-resolution structural studies of membrane-associated proteins and peptides in a
membrane environment are important to fully understand their biological function and the …

Mammalian peripherin-2 (PRPH2) and rod outer segment membrane protein 1 (ROM1) are
retina-specific tetraspanins that partake in the constant renewal of stacked membrane discs …

Abstract The FA Elongase-4 (ELOVL4) enzyme mediates biosynthesis of both very long
chain (VLC)-PUFAs and VLC-saturated FA (VLC-SFAs). VLC-PUFAs play critical roles in …

Discoidal lipid-protein nanoparticles known as nanodiscs are widely used tools in structural
and membrane biology. Amphipathic, synthetic copolymers have recently become an …