Antibiotics have transformed modern medicine. They are essential for treating infectious
diseases and enable vital therapies and procedures. However, despite this success, their …

The discharge of emerging pollutants in the industrial process poses a severe threat to the
ecological environment and human health. Photocatalytic self-Fenton technology combines …

As of January 2023, SARS-CoV-2 subvariants BQ. 1 (a BA. 5 subvariant) and XBB (a BA. 2
subvariant) have replaced previously dominant omicro n variants globally, including BA. 5 …

Acquired resistance to carbapenems in Gram-negative bacteria is mostly related to
acquisition of carbapenemhydrolysing β-lactamases, among which metallo-β-lactamases …

Infections caused by ceftolozane-tazobactam and ceftazidime-avibactam-resistant P.
aeruginosa infections are an emerging concern. We aimed to analyze the underlying …

Objectives To evaluate the in vitro antibacterial activity of cefiderocol, a siderophore
cephalosporin against MBL-producing clinical isolates. Methods MBL-producing strains …

Abstract Metallo-β-lactamases (MBLs) are zinc-dependent hydrolases that inactivate
virtually all β-lactam antibiotics. The expression of MBLs by Gram-negative bacteria severely …

Background Klebsiella pneumoniae is the most common pathogen causing neonatal
infections, leading to high mortality worldwide. Along with increasing antimicrobial use in …

Antibiotics are identified as an emerging contaminant due to their persistence in the
environment. Antibiotics, due to their accumulation in freshwater sources and wastewater …

The design of inhibitors against metallo-β-lactamases (MBLs), the largest family of
carbapenemases, has been a strategic goal in designing novel antimicrobial therapies. In …