DNA-loop extrusion is considered to be a universal principle of structural maintenance of
chromosome (SMC) proteins with regard to chromosome organization. Despite recent …

Loop extrusion constitutes a universal mechanism of genome organization, whereby
structural maintenance of chromosomes (SMC) protein complexes load onto the chromatin …

DNA nanostructures have been utilized to study biological mechanical processes and
construct artificial nanosystems. Many application scenarios necessitate nanodevices able …

Cohesin extrudes genomic DNA into loops that promote chromatin assembly, gene
regulation and recombination. Here we show that cohesin introduces negative supercoils …

Circular DNA found in the cell is actively regulated to an underwound state, with their
superhelical density close to σ~-0.06. While this underwound state is essential to life, how it …

Cohesin forms a proteinaceous ring that is thought to link sister chromatids by entrapping
DNA and counteracting the forces generated by the mitotic spindle. Whether individual …

The inheritance of genetic information depends on the duplication and transfer of
deoxyribonucleic acid (DNA) molecules from parental cells to daughter cells (1). Therefore …