The Multifaceted p21 (Cip1/Waf1/CDKN1A) in Cell Differentiation, Migration and Cancer Therapy
NN Kreis, F Louwen, J Yuan - Cancers, 2019 - mdpi.com
Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …
Mitogen signaling strength and duration can control cell cycle decisions
Decades ago, mitogen-promoted signaling duration and strength were observed to be
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …
sensed by the cell and to be critical for its decisions: to proliferate or differentiate. Landmark …
Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
Y Gao, F Souza-Fonseca-Guimaraes, T Bald… - Nature …, 2017 - nature.com
Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately
evade control by natural killer (NK) cells remains incompletely defined. Using global …
evade control by natural killer (NK) cells remains incompletely defined. Using global …
AMPK/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells
Leukemia stem cells (LSCs) are thought to drive the genesis of acute myeloid leukemia
(AML) as well as relapse following chemotherapy. Because of their unique biology …
(AML) as well as relapse following chemotherapy. Because of their unique biology …
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes
The precise timing of cell cycle gene expression is critical for the control of cell proliferation;
de-regulation of this timing promotes the formation of cancer and leads to defects during …
de-regulation of this timing promotes the formation of cancer and leads to defects during …
Gold nanoparticle-integrated scaffolds for tissue engineering and regenerative medicine
The development of scaffolding materials that recapitulate the cellular microenvironment
and provide cells with physicochemical cues is crucial for successfully engineering …
and provide cells with physicochemical cues is crucial for successfully engineering …
A single-cell survey of Drosophila blood
Drosophila blood cells, called hemocytes, are classified into plasmatocytes, crystal cells,
and lamellocytes based on the expression of a few marker genes and cell morphologies …
and lamellocytes based on the expression of a few marker genes and cell morphologies …
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies
S Christian, C Merz, L Evans, S Gradl, H Seidel… - Leukemia, 2019 - nature.com
Acute myeloid leukemia (AML) is a devastating disease, with the majority of patients dying
within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is …
within a year of diagnosis. For patients with relapsed/refractory AML, the prognosis is …
Effects and mechanisms of kaempferol in the management of cancers through modulation of inflammation and signal transduction pathways
Cancer is the principal cause of death and its incidence is increasing continuously
worldwide. Various treatment approaches are in practice to treat cancer, but these treatment …
worldwide. Various treatment approaches are in practice to treat cancer, but these treatment …
Functionalized BaTiO3 enhances piezoelectric effect towards cell response of bone scaffold
Piezoelectric effect of polyvinylidene fluoride (PVDF) plays a crucial role in restoring the
endogenous electrical microenvironment of bone tissue, whereas more β phase in PVDF …
endogenous electrical microenvironment of bone tissue, whereas more β phase in PVDF …