[HTML][HTML] Roles and mechanisms of renalase in cardiovascular disease: A promising therapeutic target

Y Li, W Wu, W Liu, M Zhou - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cardiovascular disease (CVD) is prevalent worldwide and remains a leading cause of
death. Although substantial progress has been made in the diagnosis and treatment of CVD …

Human renalase: a review of its biology, function, and implications for hypertension

GV Desir, L Wang, AJ Peixoto - Journal of the American Society of …, 2012 - Elsevier
Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes
catecholamines and catecholamine-like substances via a superoxide (O2–)-dependent …

Gene expression level of renalase in the skeletal muscles is increased with high-intensity exercise training in mice on a high-fat diet

K Tokinoya, S Ono, K Aoki, K Yanazawa… - Physiology …, 2021 - akjournals.com
Introduction Exercise training is beneficial for reducing obesity. In particular, exercise
training can lower the catecholamine concentration in circulation. Renalase, whose …

[HTML][HTML] Renalase protects the cardiomyocytes of Sprague-Dawley rats against ischemia and reperfusion injury by reducing myocardial cell necrosis and apoptosis

X Li, Z Xie, M Lin, R Huang, Z Liang, W Huang… - Kidney and Blood …, 2015 - karger.com
Background/Aims: Renalase, a novel flavoprotein expressed in the kidney and heart,
reduces renal tubular necrosis and apoptosis, which suggests that it might protect against …

Renalase protects against ischemic AKI

HT Lee, JY Kim, M Kim, P Wang, L Tang… - Journal of the …, 2013 - journals.lww.com
Elevated levels of plasma catecholamines accompany ischemic AKI, possibly contributing
the inflammatory response. Renalase, an amine oxidase secreted by the proximal tubule …

Renalase in hypertension and kidney disease

GV Desir, AJ Peixoto - Nephrology dialysis transplantation, 2014 - academic.oup.com
Renalase, a recently discovered flavoprotein, which is strongly expressed in the kidney and
heart, effectively metabolizes catecholamines. It was discovered during the search to identify …

Renalase prevents AKI independent of amine oxidase activity

L Wang, H Velazquez, G Moeckel… - Journal of the …, 2014 - journals.lww.com
AKI is characterized by increased catecholamine levels and hypertension. Renalase, a
secretory flavoprotein that oxidizes catecholamines, attenuates ischemic injury and the …

Exercise differentially regulates renalase expression in skeletal muscle and kidney

B Czarkowska-Paczek… - The Tohoku Journal of …, 2013 - jstage.jst.go.jp
Renalase is a newly discovered amine oxidase and may lower blood pressure by
metabolizing catecholamines. We have hypothesized that exercise and training may …

Identification of a receptor for extracellular renalase

L Wang, H Velazquez, J Chang, R Safirstein, GV Desir - PloS one, 2015 - journals.plos.org
Background An increased risk for developing essential hypertension, stroke and diabetes is
associated with single nucleotide gene polymorphisms in renalase, a newly described …

Extracellular renalase protects cells and organs by outside‐in signalling

Y Wang, R Safirstein, H Velazquez… - Journal of cellular …, 2017 - Wiley Online Library
Renalase was discovered as a protein synthesized by the kidney and secreted in blood
where it circulates at a concentration of approximately 3–5 μg/ml. Initial reports suggested …