Impaired melatonin secretion, oxidative stress and metabolic syndrome in night shift work

S Hohor, C Mandanach, A Maftei, CA Zugravu… - Antioxidants, 2023 - mdpi.com
Metabolic syndrome has been associated in many studies with working in shifts. Even if the
mechanistic details are not fully understood, forced sleep deprivation and exposure to light …

[HTML][HTML] Melatonin protects the heart and pancreas by improving glucose homeostasis, oxidative stress, inflammation and apoptosis in T2DM-induced rats

DA Abdulwahab, MA El-Missiry, S Shabana, AI Othman… - Heliyon, 2021 - cell.com
Cardiomyopathy and pancreatic injury are health issues associated with type 2 diabetes
mellitus (T2DM) and are characterized by elevated oxidative stress, inflammation and …

Utility of melatonin in mitigating ionizing radiation-induced testis injury through synergistic interdependence of its biological properties

ME Amer, AI Othman, HM Abozaid, MA El-Missiry - Biological Research, 2022 - Springer
Background Ionizing radiations (IR) have widespread useful applications in our daily life;
however, they have unfavorable effects on reproductive health. Maintaining testicular health …

New advances on pathophysiology of diabetes neuropathy and pain management: potential role of melatonin and DPP-4 inhibitors

P Busa, Y Kuthati, N Huang, CS Wong - Frontiers in pharmacology, 2022 - frontiersin.org
Pre-diabetes and diabetes are growing threats to the modern world. Diabetes mellitus (DM)
is associated with comorbidities such as hypertension (83.40%), obesity (90.49%), and …

Protective effects of chronic humanin treatment in mice with diabetic encephalopathy: A focus on oxidative stress, inflammation, and apoptosis

F Bulut, M Adam, A Özgen, MG Hekim, S Ozcan… - Behavioural brain …, 2023 - Elsevier
Diabetes is known to cause cognitive impairments through various mechanisms, including
oxidative stress, inflammation, and apoptosis. Humanin (HN) has been shown to have …

Constant light exposure and/or pinealectomy increases susceptibility to trichloroethylene-induced hepatotoxicity and liver cancer in male mice

ME Abdraboh, MA El-Missiry, AI Othman… - … Science and Pollution …, 2022 - Springer
Exposure to light at night, pineal gland impairment, and the environmental pollutant
trichloroethylene (TCE) have serious implications for health and contribute to illness …

Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice

ME Amer, MA Amer, AI Othman, DA Elsayed… - Molecular Biology …, 2022 - Springer
Background Plant-derived phytochemicals have been reported to exert anticancer activity.
This study investigated the antitumor role of silymarin (Silybum marianum)(SMN) and its …

Melatonin ameliorates the adrenal and pancreatic alterations in streptozotocin-induced diabetic rats: clinical, biochemical, and descriptive histopathological studies

AAA Oyouni, OM Al-Amer, FAZ Ali… - Frontiers in Veterinary …, 2022 - frontiersin.org
Previous studies have demonstrated the beneficial effects of melatonin in diabetic rats.
However, limited studies have been conducted on the potential effects of melatonin on the …

Nociceptin increases antioxidant expression in the kidney, liver and brain of diabetic rats

E Adeghate, CM D'Souza, Z Saeed, S Al Jaberi… - Biology, 2021 - mdpi.com
Simple Summary Nociceptin (NC) is a small peptide implicated in the physiology of pain,
learning and memory. Here we investigated the role of NC in the induction of antioxidants in …

Epigallocatechin-3-gallate enhances cognitive and memory performance and protects against brain injury in methionine-induced Hyperhomocysteinemia through …

MD Mostafa, MA ElKomy, AI Othman, ME Amer… - Neurotoxicity …, 2022 - Springer
Brain injury and cognitive impairment are major health issues associated with
neurodegenerative diseases in young and aged persons worldwide. Epigallocatechin-3 …