Diversity and versatility of p38 kinase signalling in health and disease
B Canovas, AR Nebreda - Nature reviews Molecular cell biology, 2021 - nature.com
The ability of cells to deal with different types of stressful situations in a precise and
coordinated manner is key for survival and involves various signalling networks. Over the …
coordinated manner is key for survival and involves various signalling networks. Over the …
Stress relief techniques: p38 MAPK determines the balance of cell cycle and apoptosis pathways
RH Whitaker, JG Cook - Biomolecules, 2021 - mdpi.com
Protein signaling networks are formed from diverse and inter-connected cell signaling
pathways converging into webs of function and regulation. These signaling pathways both …
pathways converging into webs of function and regulation. These signaling pathways both …
Long‐term expanding human airway organoids for disease modeling
N Sachs, A Papaspyropoulos… - The EMBO …, 2019 - embopress.org
Organoids are self‐organizing 3D structures grown from stem cells that recapitulate
essential aspects of organ structure and function. Here, we describe a method to establish …
essential aspects of organ structure and function. Here, we describe a method to establish …
Hypoxia drives breast tumor malignancy through a TET–TNFα–p38–MAPK signaling axis
Hypoxia is a hallmark of solid tumors that drives malignant progression by altering
epigenetic controls. In breast tumors, aberrant DNA methylation is a prevalent epigenetic …
epigenetic controls. In breast tumors, aberrant DNA methylation is a prevalent epigenetic …
Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis
X Gao, M Zhang, Y Tang, X Liang - OncoTargets and therapy, 2017 - Taylor & Francis
More recently, disease metastasis and relapse in many cancer patients several years (even
some decades) after surgical remission are regarded as tumor dormancy. However, the …
some decades) after surgical remission are regarded as tumor dormancy. However, the …
Predicting progression to Alzheimer's disease with human hippocampal progenitors exposed to serum
A Maruszak, E Silajdžić, H Lee, T Murphy, B Liu, L Shi… - Brain, 2023 - academic.oup.com
Adult hippocampal neurogenesis is important for learning and memory and is altered early
in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory …
in Alzheimer's disease. As hippocampal neurogenesis is modulated by the circulatory …
SF3B1 mutant-induced missplicing of MAP3K7 causes anemia in myelodysplastic syndromes
YK Lieu, Z Liu, AM Ali, X Wei… - Proceedings of the …, 2022 - National Acad Sciences
SF3B1 is the most frequently mutated RNA splicing factor in cancer, including in∼ 25% of
myelodysplastic syndromes (MDS) patients. SF3B1-mutated MDS, which is strongly …
myelodysplastic syndromes (MDS) patients. SF3B1-mutated MDS, which is strongly …
The role of chondroitin sulfate in regulating hypertrophy during MSC chondrogenesis in a cartilage mimetic hydrogel under dynamic loading
EA Aisenbrey, SJ Bryant - Biomaterials, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising for cartilage regeneration, but readily
undergo terminal differentiation. The aim of this study was two-fold: a) investigate …
undergo terminal differentiation. The aim of this study was two-fold: a) investigate …
p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner
Bone mass is determined by the balance between bone formation, carried out by
mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte …
mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte …
SnapShot: p38 MAPK signaling
N Trempolec, N Dave-Coll, AR Nebreda - Cell, 2013 - cell.com
SnapShot: p38 MAPK Signaling Page 1 STE20 kinases, Rho GTPases, TRAF ubiquitin ligases
ASK1, DLK1, MEKK3, MEKK4, MLK3, TAK1, TAO1, TAO2, TPL2, ZAK1 MKK4, MKK3, MKK6 …
ASK1, DLK1, MEKK3, MEKK4, MLK3, TAK1, TAO1, TAO2, TPL2, ZAK1 MKK4, MKK3, MKK6 …