Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes
that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic …

Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …

Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …

Metabolic rewiring underlies the effector functions of macrophages,–, but the mechanisms
involved remain incompletely defined. Here, using unbiased metabolomics and stable …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Aging is typified by a progressive decline in mitochondrial activity and stress resilience.
Here, we review how mitochondrial stress pathways have pleiotropic effects on cellular and …

Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial
DNA recognition by intracellular DNA sensors. However, the involvement of mitochondrial …

Macrophage‐stimulator of interferon genes (STING) signaling mediated sterile inflammation
has been implicated in various age‐related diseases. However, whether and how …

Type I interferon (IFN) signalling is tightly controlled. Upon recognition of DNA by cyclic GMP-
AMP synthase (cGAS), stimulator of interferon genes (STING) translocates along the …

Background & Aims XBP1 modulates the macrophage proinflammatory response, but its
function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is …