Difference in the lipid nanoparticle technology employed in three approved siRNA (Patisiran) and mRNA (COVID-19 vaccine) drugs
Y Suzuki, H Ishihara - Drug Metabolism and Pharmacokinetics, 2021 - Elsevier
Nucleic acid therapeutics are developing into precise medicines that can manipulate
specific genes. However, the development of safe and effective delivery system for the target …
specific genes. However, the development of safe and effective delivery system for the target …
An overview of the Stability and Delivery challenges of Commercial Nucleic Acid therapeutics
RG Ingle, WJ Fang - Pharmaceutics, 2023 - mdpi.com
Nucleic acid (NA)-based biopharmaceuticals have emerged as promising therapeutic
modalities. NA therapeutics are a diverse class of RNA and DNA and include antisense …
modalities. NA therapeutics are a diverse class of RNA and DNA and include antisense …
Adverse effects and antibody titers in response to the BNT162b2 mRNA COVID-19 vaccine in a prospective study of healthcare workers
SAA Coggins, ED Laing, CH Olsen… - Open Forum …, 2022 - academic.oup.com
Background The relationship between postvaccination symptoms and strength of antibody
responses is unclear. The goal of this study was to determine whether adverse effects …
responses is unclear. The goal of this study was to determine whether adverse effects …
Reducing cell intrinsic immunity to mRNA vaccine alters adaptive immune responses in mice
Z Wang, EJ Jacobus, DC Stirling, S Krumm… - … Therapy-Nucleic Acids, 2023 - cell.com
The response to mRNA vaccines needs to be sufficient for immune cell activation and
recruitment, but moderate enough to ensure efficacious antigen expression. The choice of …
recruitment, but moderate enough to ensure efficacious antigen expression. The choice of …
An mRNA vaccine encoding the SARS-CoV-2 receptor-binding domain protects mice from various Omicron variants
R Uraki, M Imai, M Ito, S Yamayoshi, M Kiso, N Jounai… - npj Vaccines, 2024 - nature.com
Here, we assessed the efficacy of a lipid nanoparticle-based mRNA vaccine candidate
encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with …
encoding the receptor-binding domain (LNP-mRNA-RBD) in mice. Mice immunized with …
Medical imaging of pulmonary disease in SARS-CoV-2-exposed non-human primates
MA Stammes, JH Lee, L Meijer, T Naninck… - Trends in Molecular …, 2022 - cell.com
Chest X-ray (CXR), computed tomography (CT), and positron emission tomography–
computed tomography (PET-CT) are noninvasive imaging techniques widely used in human …
computed tomography (PET-CT) are noninvasive imaging techniques widely used in human …
mRNA vaccine designs for optimal adjuvanticity and delivery
Y Mochida, S Uchida - RNA biology, 2024 - Taylor & Francis
Adjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA
vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the …
vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the …
Predicting the presence of infectious virus from PCR data: A meta-analysis of SARS-CoV-2 in non-human primates
CE Snedden, JO Lloyd-Smith - PLoS Pathogens, 2024 - journals.plos.org
Researchers and clinicians often rely on molecular assays like PCR to identify and monitor
viral infections, instead of the resource-prohibitive gold standard of viral culture. However, it …
viral infections, instead of the resource-prohibitive gold standard of viral culture. However, it …
Establishment of a nonhuman primate model for development of vaccines and anti-viral drugs against COVID-19
Y ITOH - Translational and Regulatory Sciences, 2021 - jstage.jst.go.jp
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and has continued to spread worldwide since late 2019 [1]. It was speculated that SARS …
and has continued to spread worldwide since late 2019 [1]. It was speculated that SARS …