Pathogenesis and virulence of Candida albicans

JP Lopes, MS Lionakis - Virulence, 2022 - Taylor & Francis
Candida albicans is a commensal yeast fungus of the human oral, gastrointestinal, and
genital mucosal surfaces, and skin. Antibiotic-induced dysbiosis, iatrogenic …

The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives

C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

[HTML][HTML] Vulvovaginal candidiasis: a current understanding and burning questions

HME Willems, SS Ahmed, J Liu, Z Xu, BM Peters - Journal of Fungi, 2020 - mdpi.com
Candida albicans, along with other closely related Candida species, are the primary
causative agents of vulvovaginal candidiasis (VVC)—a multifactorial infectious disease of …

Sialoglycans and siglecs can shape the tumor immune microenvironment

S van de Wall, KCM Santegoets, EJH van Houtum… - Trends in …, 2020 - cell.com
Sialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor
cells and have emerged as potent regulatory molecules involved in creating a tumor …

Siglec-15 as an emerging target for next-generation cancer immunotherapy

J Sun, Q Lu, MF Sanmamed, J Wang - Clinical Cancer Research, 2021 - AACR
Immunomodulatory agents blocking the PD-1/PD-L1 pathway have shown a new way to
treat cancer. The explanation underlying the success of these agents may be the selective …

[HTML][HTML] Recurrent vulvovaginal candidiasis: an immunological perspective

D Rosati, M Bruno, M Jaeger, J Ten Oever, MG Netea - Microorganisms, 2020 - mdpi.com
Vulvovaginal candidiasis (VVC) is a widespread vaginal infection primarily caused by
Candida albicans. VVC affects up to 75% of women of childbearing age once in their life …

Discovery, classification, evolution and diversity of Siglecs

T Angata, A Varki - Molecular aspects of medicine, 2023 - Elsevier
Immunoglobulin (Ig) superfamily proteins play diverse roles in vertebrates, including
regulation of cellular responses by sensing endogenous or exogenous ligands. Siglecs are …

[HTML][HTML] Structural insights into Siglec-15 reveal glycosylation dependency for its interaction with T cells through integrin CD11b

MP Lenza, L Egia-Mendikute… - Nature …, 2023 - nature.com
Sialic acid-binding Ig-like lectin 15 (Siglec-15) is an immune modulator and emerging
cancer immunotherapy target. However, limited understanding of its structure and …

[HTML][HTML] It Takes Two to Tango: How a Dysregulation of the Innate Immunity, Coupled With Candida Virulence, Triggers VVC Onset

A Ardizzoni, RT Wheeler, E Pericolini - Frontiers in Microbiology, 2021 - frontiersin.org
Vulvovaginal candidiasis (VVC) is a symptomatic inflammation of the vagina mainly caused
by C. albicans. Other species, such as C. parapsilosis, C. glabrata, C. tropicalis, and C …

Ibrexafungerp for the treatment of vulvovaginal candidiasis: design, development and place in therapy

NA Phillips, M Rocktashel… - Drug design, development …, 2023 - Taylor & Francis
Vulvovaginal candidiasis (VVC) is experienced by an estimated 75% of women at least once
in their lifetime and is recurrent, defined as three or more infections per year (RVVC) in 5 …