Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

Late-stage functionalization for improving drug-like molecular properties

NJ Castellino, AP Montgomery, JJ Danon… - Chemical …, 2023 - ACS Publications
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …

DNA-based platform for efficient and precisely targeted bioorthogonal catalysis in living systems

Y You, Q Deng, Y Wang, Y Sang, G Li, F Pu… - Nature …, 2022 - nature.com
As one of the typical bioorthogonal reactions, copper (I)-catalyzed azide-alkyne
cycloaddition (CuAAC) reaction holds great potential in organic synthesis, bioconjugation …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Decatungstate as direct hydrogen atom transfer photocatalyst for SOMOphilic alkynylation

L Capaldo, D Ravelli - Organic Letters, 2021 - ACS Publications
A versatile approach for the alkynylation of a variety of aliphatic hydrogen donors, including
alkanes, is reported. We used tetrabutylammonium decatungstate as photocatalyst to …

Bioconjugation in materials science

C Bednarek, U Schepers, F Thomas… - Advanced Functional …, 2024 - Wiley Online Library
With the advent of bioconjugation chemistry in the last two decades, highlighted by the
Nobel Prize 2022, the quest for possible novel applications has been greatly intensified …

Machine Learning‐Guided Computational Screening of New Candidate Reactions with High Bioorthogonal Click Potential

T Stuyver, CW Coley - Chemistry–A European Journal, 2023 - Wiley Online Library
Bioorthogonal click chemistry has become an indispensable part of the biochemist's toolbox.
Despite the wide variety of applications that have been developed in recent years, only a …

Metabolic labeling strategy boosted antibacterial efficiency for photothermal and photodynamic synergistic bacteria-infected wound therapy

N Li, G Wu, L Tang, W Zhou, S Yang… - … Applied Materials & …, 2022 - ACS Publications
Pathogenic bacteria infections bring about a substantial risk to human health. Given the
development of antibiotic-resistance bacteria, alternative antibacterial strategies with great …

Design and Development of a Bioorthogonal, Visualizable and Mitochondria‐Targeted Hydrogen Sulfide (H2S) Delivery System

Y Chen, R Zhao, C Tang, C Zhang, W Xu… - Angewandte …, 2022 - Wiley Online Library
Hydrogen sulfide (H2S) is an important endogenous gasotransmitter, but the targeted
delivery and real‐time feedback of exogenous H2S are still challenging. With the aid of …

Forgotten and forbidden chemical reactions revitalised through continuous flow technology

A Bonner, A Loftus, AC Padgham… - Organic & Biomolecular …, 2021 - pubs.rsc.org
Continuous flow technology has played an undeniable role in enabling modern chemical
synthesis, whereby a myriad of reactions can now be performed with greater efficiency …