The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

Ethylene is the byproduct of olefin metathesis reactions that involve one or more terminal
alkenes. Its volatility is one reason why many cross‐metathesis or ring‐closing metathesis …

Amides are a class of easily available compounds, and widely serve as versatile
intermediates in organic synthesis and medicinal chemistry. Amide-based transformations …

Nucleophilic addition to amides has been recognized as a promising transformation for total
synthesis of complex alkaloids. Amides can accept two different organometallic reagents …

A chemoselective approach for the total synthesis of (±)‐gephyrotoxin has been developed.
The key to success was the utilization of N‐methoxyamides, which enabled the direct …

Iridium-catalyzed reductive nucleophilic addition to N-methoxyamides is reported. The
reaction took place in high yields in the presence of a variety of sensitive functional groups …

Ring-rearrangement metathesis (RRM) involves multiple metathesis processes such as ring-
opening metathesis (ROM)/ring-closing metathesis (RCM) in a one-pot operation to …

An amide group is one of the most abundant functional groups in organic synthesis.
However, nucleophilic addition to amide carbonyls has received less attention than their …

The nitrosocarbonyls (R–CONO) are highly reactive species and remarkable intermediates
toward different synthetic targets. This review will cover a research area whose impact in …

As the complexity of targeted molecules increases in modern organic synthesis,
chemoselectivity is recognized as an important factor in the development of new …