Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

Gene expression occurs in two essential steps: transcription and translation. In bacteria, the
two processes are tightly coupled in time and space, and highly regulated. Tight regulation …

Background: Multi-drug-resistant bacteria such as Methicillin-Resistant Staphylococcus
aureus (MRSA) disseminate rapidly amongst patients in healthcare facilities and suppose …

Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …

The amount of bacterial and archaeal genome sequence and methylome data has greatly
increased over the last decade, enabling new insights into the functional roles of DNA …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

The discovery of antibiotics in the last century is considered one of the most important
achievements in the history of medicine. Antibiotic usage has significantly reduced morbidity …

The pursuit of highly sensitive and specific cancer diagnostics based on cell‐free nucleic
acids isolated from minimally invasive liquid biopsies has been an area of intense research …

Abstract DNA N6-adenine methylation (6mA) has recently gained importance as an
epigenetic modification in eukaryotes. Its function in lineages with high levels, such as early …