The HDL Proteome Watch: Compilation of studies leads to new insights on HDL function

WS Davidson, AS Shah, H Sexmith… - Biochimica et Biophysica …, 2022 - Elsevier
Purpose of review High density lipoproteins (HDL) are a heterogeneous family of particles
that contain distinct complements of proteins that define their function. Thus, it is important to …

Alterations of HDL's to piHDL's proteome in patients with chronic inflammatory diseases, and HDL-targeted therapies

V Vyletelová, M Nováková, Ľ Pašková - Pharmaceuticals, 2022 - mdpi.com
Chronic inflammatory diseases, such as rheumatoid arthritis, steatohepatitis, periodontitis,
chronic kidney disease, and others are associated with an increased risk of atherosclerotic …

Current understanding of the relationship of HDL composition, structure and function to their cardioprotective properties in chronic kidney disease

G Marsche, GH Heine, JT Stadler, M Holzer - Biomolecules, 2020 - mdpi.com
In the general population, the ability of high-density lipoproteins (HDLs) to promote
cholesterol efflux is a predictor of cardiovascular events, independently of HDL cholesterol …

Reproducible determination of high-density lipoprotein proteotypes

S Goetze, K Frey, L Rohrer… - Journal of proteome …, 2021 - ACS Publications
High-density lipoprotein (HDL) is a heterogeneous mixture of blood-circulating
multimolecular particles containing many different proteins, lipids, and RNAs. Recent …

ANGPTL3 (Angiopoietin‐Like 3) preferentially resides on High‐density lipoprotein in the human circulation, affecting its activity

JM Kraaijenhof, TR Tromp… - Journal of the …, 2023 - Am Heart Assoc
Background ANGPTL3 (angiopoietin‐like protein 3) is an acknowledged crucial regulator of
lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase …

Searching for Atherosclerosis Biomarkers by Proteomics: A Focus on Lesion Pathogenesis and Vulnerability

G Nieddu, M Formato, AJ Lepedda - International Journal of Molecular …, 2023 - mdpi.com
Plaque rupture and thrombosis are the most important clinical complications in the
pathogenesis of stroke, coronary arteries, and peripheral vascular diseases. The …

[HTML][HTML] Impact of reduced apolipoprotein AI levels on pulmonary arterial hypertension

Y Huang, J Zhang, Q Zhao, X Hu, H Zhao… - Hellenic Journal of …, 2024 - Elsevier
Objective The significance of apolipoprotein AI (ApoA-I) is the anti-inflammatory functional
component of high-density lipoprotein, which needs to be further studied in relation to …

Proteomic and functional analysis of HDL subclasses in humans and rats: a proof-of-concept study

C Huang, J Zhang, J Huang, H Li, K Wen, J Bao… - Lipids in Health and …, 2023 - Springer
Background The previous study investigated whether the functions of small, medium, and
large high density lipoprotein (S/M/L-HDL) are correlated with protein changes in mice …

Enrichment of apolipoprotein A-IV and apolipoprotein D in the HDL proteome is associated with HDL functions in diabetic kidney disease without dialysis

MFM Santana, ALA Lira, RS Pinto, CA Minanni… - Lipids in Health and …, 2020 - Springer
Background and aims Diabetic kidney disease (DKD) is associated with lipid derangements
that worsen kidney function and enhance cardiovascular (CVD) risk. The management of …

Aloe vera supplementation improves cardiovascular risk factors in hemodialysis patients: A randomized, double-blind, placebo-controlled trial

A Kooshki, MR Memarzadeh… - Avicenna Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Objective: This study assessed the effects of Aloe vera supplementation on serum
inflammatory factors, blood sugar and lipid profiles in hemodialysis patients. Materials and …