SGLT2 (sodium-glucose cotransporter 2) inhibitors interfere with the reabsorption of glucose
and sodium in the early proximal renal tubule, but the magnitude and duration of any …

Daily dietary potassium (K+) intake may be as large as the extracellular K+ pool. To avoid
acute hyperkalemia, rapid removal of K+ from the extracellular space is essential. This is …

Acute kidney injury (AKI) is a major public health problem that complicates 10–40% of
hospital admissions. Importantly, AKI is independently associated with increased risk of …

The with no lysine (K)(WNK) kinases are an evolutionarily ancient group of kinases with
atypical placement of the catalytic lysine and diverse physiological roles. Recent studies …

Hypertension is the single most important and modifiable risk factor for cardiovascular
morbidity and mortality worldwide. Non pharmacologic interventions, in particular dietary …

The inwardly rectifying potassium channel (Kir) 4.1 (encoded by KCNJ10) interacts with Kir5.
1 (encoded by KCNJ16) to form a major basolateral K+ channel in the renal distal …

K+ deficiency stimulates renal salt reuptake via the Na+-Cl− cotransporter (NCC) of the
distal convoluted tubule (DCT), thereby reducing K+ losses in downstream nephron …

In recent years, cation-chloride cotransporters (CCCs) have drawn attention in the medical
neuroscience research. CCCs include the family of Na+-coupled Cl-importers (NCC …

Vasopressin regulates water homeostasis via the V2 receptor in the kidney at least in part
through protein kinase A (PKA) activation. Vasopressin, through an unknown pathway …

The with-no-lysine kinase 4 (WNK4)-sterile 20/SPS-1-related proline/alanine-rich kinase
(SPAK)/oxidative stress-responsive kinase 1 (OSR1) pathway mediates activating …