Understanding how chromatin is folded in the nucleus is fundamental to understanding its
function. Although 3D genome organization has been historically difficult to study owing to a …

We investigated genome folding across the eukaryotic tree of life. We find two types of three-
dimensional (3D) genome architectures at the chromosome scale. Each type appears and …

Recent experimental observations suggest a strong coupling between the 3D nuclear
chromosome organization and epigenomics. However, the mechanistic and functional …

Nuclear compartments are prominent features of 3D chromatin organization, but sequencing
depth limitations have impeded investigation at ultra fine-scale. CTCF loops are generally …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Which signaling pathway and protein to select to mitigate the patient's expected drug
resistance? The number of possibilities facing the physician is massive, and the drug …

Using computer simulations, we generate cell-specific 3D chromosomal structures and
compare them to recently published chromatin structures obtained through microscopy. We …

In recent years, much effort has been devoted to understanding the three-dimensional (3D)
organization of the genome and how genomic structure mediates nuclear function. The …

The folding patterns of interphase genomes in higher eukaryotes, as obtained from DNA-
proximity-ligation or Hi-C experiments, are used to classify loci into structural classes called …

The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …