AMPK as a therapeutic target for treating metabolic diseases

EA Day, RJ Ford, GR Steinberg - Trends in Endocrinology & Metabolism, 2017 - cell.com
The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

[HTML][HTML] Extraction, structure, and activity of polysaccharide from Radix astragali

Z Tang, G Huang - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Radix astragali polysaccharide (RAP) is a water-soluble heteropolysaccharide. It is an
immune promoter and regulator, and has antivirus, antitumor, anti-aging, anti-radiation, anti …

[HTML][HTML] Anti-aging implications of Astragalus membranaceus (Huangqi): a well-known Chinese tonic

P Liu, H Zhao, Y Luo - Aging and disease, 2017 - ncbi.nlm.nih.gov
Owing to a dramatic increase in average life expectancy and the Family Planning program of
the 1970s-1990s, China is rapidly becoming an aging society. Therefore, the investigation of …

A review of recent research progress on the astragalus genus

X Li, L Qu, Y Dong, L Han, E Liu, S Fang, Y Zhang… - Molecules, 2014 - mdpi.com
Astragalus L., is one of the largest genuses of flowering plants in the Leguminosae family.
Roots of A. membranaceus Bge. var. mongholicus (Bge.) Hsiao, A. membranaceus (Fisch.) …

Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune …

OA Bamodu, KT Kuo, CH Wang, WC Huang, ATH Wu… - Nutrients, 2019 - mdpi.com
Background: Recently, we demonstrated that Astragalus polysaccharide (PG2), the active
ingredient in dried roots of astragalus membranaceus, ameliorates cancer symptom clusters …

Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-κВ activation

J Lv, Y Zhang, Z Tian, F Liu, Y Shi, Y Liu… - International Journal of …, 2017 - Elsevier
Astragalus polysaccharide (APS) is a bioactive extract of Astragalus membranaceus (AM),
which possess a wide range of medicinal benefits, including anti-inflammatory, anti …

Astragalus polysaccharides and saponins alleviate liver injury and regulate gut microbiota in alcohol liver disease mice

J Zhou, N Zhang, L Zhao, W Wu, L Zhang, F Zhou, J Li - Foods, 2021 - mdpi.com
Astragalus, a medical and edible plant in China, shows several bioactive properties.
However, the role of astragalus in attenuating alcoholic liver disease (ALD) is less clear. The …

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

G Ding, Q Gong, J Ma, X Liu, Y Wang… - Cancer science, 2021 - Wiley Online Library
Astragalus polysaccharides (APS), the main effective component of Astragalus
membranaceus, can inhibit tumor growth, but the underlying mechanisms remain unclear …

Astragalus membranaceus-Polysaccharides Ameliorates Obesity, Hepatic Steatosis, Neuroinflammation and Cognition Impairment without Affecting Amyloid …

YC Huang, HJ Tsay, MK Lu, CH Lin, CW Yeh… - International journal of …, 2017 - mdpi.com
Astragalus membranaceus is commonly used in traditional Chinese medicine for
strengthening the host defense system. Astragalus membranaceus-polysaccharides is an …

Covalent inhibition of endoplasmic reticulum chaperone GRP78 disconnects the transduction of ER stress signals to inflammation and lipid accumulation in diet …

D Luo, N Fan, X Zhang, FY Ngo, J Zhao, W Zhao… - Elife, 2022 - elifesciences.org
Targeting endoplasmic reticulum (ER) stress, inflammation, and metabolic dysfunctions may
halt the pathogenesis of obesity and thereby reduce the prevalence of diabetes …