CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …

Bone cancers are characterised by the development of tumour cells in bone sites,
associated with a dysregulation of their environment. In the last two decades, numerous …

More than 85% of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), or “Ewing
family of tumors”(EFTs), have the translocation, t (11; 22)(q24; q12), with others having …

Background Imatinib mesylate is a small molecule inhibitor of certain tyrosine kinases, most
notably the chimeric bcr‐abl fusion protein found in CML. It also inhibits KIT and PDGF …

Ewing sarcoma, the second most frequent bone cancer type, affects mainly adolescents,
who have a survival of 50% 5 yr after diagnosis. Current treatments include a combination of …

Development of chemotherapeutic treatment modalities resulted in a dramatic increase in
the survival of children with many types of cancer. Still, in case of some pediatric cancer …

Purpose: Ewing tumor cell survival and proliferation depends on several autocrine loops.
Targeting these loops is a promising therapeutic approach. We recently showed the …

Ewing's family tumor (EFT) is a rare pediatric tumor of unclear origin that occurs in bone and
soft tissue. Specific chromosomal translocations found in EFT cause EWS to fuse to a subset …

Background The transmembrane protein c-kit is a receptor tyrosine kinase (KIT) and KIT is
expressed in solid tumors and hematological malignancies such as gastrointestinal stromal …

Introduction: Ewing sarcoma (ES) represents the paradigm of an aberrant E-twenty-six (ETS)
oncogene-driven cancer. It is characterized by specific rearrangements of one of five …