The effects of temperature on cellular physiology
Temperature impacts biological systems across all length and timescales. Cells and the
enzymes that comprise them respond to temperature fluctuations on short timescales, and …
enzymes that comprise them respond to temperature fluctuations on short timescales, and …
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans
Lipid and carbohydrate metabolism are highly conserved processes that affect nearly all
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
aspects of organismal biology. Caenorhabditis elegans eat bacteria, which consist of lipids …
An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
Regulation of lipid saturation without sensing membrane fluidity
Cells maintain membrane fluidity by regulating lipid saturation, but the molecular
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
mechanisms of this homeoviscous adaptation remain poorly understood. We have …
Emerging roles for lipids in non-apoptotic cell death
Non-apoptotic regulated cell death (RCD) is essential to maintain organismal homeostasis
and may be aberrantly activated during certain pathological states. Lipids are emerging as …
and may be aberrantly activated during certain pathological states. Lipids are emerging as …
Principles of membrane adaptation revealed through environmentally induced bacterial lipidome remodeling
Cells, from microbes to mammals, adapt their membrane lipid composition in response to
environmental changes to maintain optimal properties. Global patterns of lipidome …
environmental changes to maintain optimal properties. Global patterns of lipidome …
iPGK-PseAAC: identify lysine phosphoglycerylation sites in proteins by incorporating four different tiers of amino acid pairwise coupling information into the general …
LM Liu, Y Xu, KC Chou - Medicinal Chemistry, 2017 - ingentaconnect.com
Background: Occurring at Lys residues, the PGK (lysine phosphoglycerylation) is a special
kind of post-translational modification (PTM). It may invert the charge potential of the …
kind of post-translational modification (PTM). It may invert the charge potential of the …
iPreny-PseAAC: identify C-terminal cysteine prenylation sites in proteins by incorporating two tiers of sequence couplings into PseAAC
Y Xu, Z Wang, C Li, KC Chou - Medicinal Chemistry, 2017 - ingentaconnect.com
Background: Occurring at the cysteine residue in the C-terminal of a protein, prenylation is a
special kind of post-translational modification (PTM), which may play a key role for statin in …
special kind of post-translational modification (PTM), which may play a key role for statin in …
Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms
N van den Tempel, MR Horsman… - International journal of …, 2016 - Taylor & Francis
It has long been established that hyperthermia increases the therapeutic benefit of radiation
and chemotherapy in cancer treatment. During the last few years there have been …
and chemotherapy in cancer treatment. During the last few years there have been …
Enhancing nutritional niche and host defenses by modifying the gut microbiome
The gut microbiome is essential for processing complex food compounds and synthesizing
nutrients that the host cannot digest or produce, respectively. New model systems are …
nutrients that the host cannot digest or produce, respectively. New model systems are …