Drug discovery and development is a high-risk, expensive endeavor and it commonly takes about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …
A Palmer, P Phapale, I Chernyavsky, R Lavigne… - Nature …, 2017 - nature.com
High-mass-resolution imaging mass spectrometry promises to localize hundreds of metabolites in tissues, cell cultures, and agar plates with cellular resolution, but it is …
Amphiphiles, either synthetic or natural, are structurally simple molecules with the unprecedented capacity to self-assemble into complex, hierarchical geometries in …
W Zhang, D Zhang, Q Chen, J Wu, Z Ouyang… - Nature …, 2019 - nature.com
Mass spectrometry-based lipidomics is the primary tool for the structural analysis of lipids but the effective localization of carbon–carbon double bonds (C= C) in unsaturated lipids to …
Cellular lipidome is highly regulated through lipogenesis, rendering diverse double-bond positional isomers (C═ C isomer) of a given unsaturated lipid species. In recent years, there …
Matrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) is a powerful technique for visualising the spatial locations of lipids in biological tissues …
J Kriegsmann, M Kriegsmann… - … journal of oncology, 2014 - spandidos-publications.com
Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) imaging mass spectrometry (IMS) is an evolving technique in cancer diagnostics and combines the …
Mass spectrometry imaging (MSI) has accelerated our understanding of lipid metabolism and spatial distribution in tissues and cells. However, few MSI studies have approached lipid …
Mass spectrometry imaging (MSI) is a powerful analytical technique that enables label-free spatial localization and identification of molecules in complex samples. 1− 4 MSI …