[HTML][HTML] Trigonelline prevents kidney stone formation processes by inhibiting calcium oxalate crystallization, growth and crystal-cell adhesion, and downregulating …

P Peerapen, W Boonmark, V Thongboonkerd - Biomedicine & …, 2022 - Elsevier
Trigonelline is the second most abundant bioactive alkaloid found in coffee. It is classified as
a phytoestrogen with similar structure as of estradiol and exhibits an estrogenic effect. A …

Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi‐target pharmacology of fenugreek against diabetes

W Luo, J Deng, J He, L Yin, R You… - Journal of Cellular …, 2023 - Wiley Online Library
Fenugreek is an ancient herb that has been used for centuries to treat diabetes. However,
how the fenugreek‐derived chemical compounds work in treating diabetes remains …

Preclinical pharmacokinetics of 4-hydroxy isoleucine using LC–MS/MS: a potential polycystic ovary syndrome phytopharmaceutical therapeutics

S Agrawal, SN Sanap, AC Bisen, A Biswas… - Bioanalysis, 2023 - Taylor & Francis
Aim: To study the preclinical pharmacokinetics of 4-hydroxy isoleucine (4-HIL) targeted for
polycystic ovary syndrome. Methodology: The quantitative bioanalysis of 4-HIL in different …

Simultaneous pharmacokinetic assessment of phytopharmaceuticals in fenugreek extract using LC–MS/MS in Sprague–Dawley rats

S Agrawal, AC Bisen, A Biswas… - Biomedical …, 2023 - Wiley Online Library
Fenugreek seeds are used in numerous marketed herbal formulations with therapeutic
benefits. Some of its bioactive components such as 4‐hydroxyisoleucine, trigonelline …

The Flavonoid Rich Black Currant (Ribes nigrum) Ethanolic Gemmotherapy Extract Elicits Neuroprotective Effect by Preventing Microglial Body Swelling in Hippocampus and …

T Téglás, E Mihok, Z Cziáky, NK Oláh, C Nyakas… - Molecules, 2023 - mdpi.com
Many plant-derived flavonoids are known for their anti-neuroinflammatory and anti-
neurodegenerative effects. The fruits and leaves of the black currant (BC, Ribes nigrum) …

[HTML][HTML] Quality-controlled LC-ESI-MS food metabolomics of fenugreek (Trigonella foenum-graecum) sprouts: Insights into changes in primary and specialized …

S Gonda, Z Szűcs, T Plaszkó, Z Cziáky… - Food Research …, 2023 - Elsevier
Fenugreek (Trigonella foenum-graecum L.) is an important food and spice with bioactive
compounds against diabetes. In this study, fenugreek seeds germinating in darkness for 72 …

Rapid Analysis of 18 Flavonoids in Tea by Ultrahigh‐Performance Liquid Chromatography Coupled with Quadrupole‐Time of Flight Mass Spectrometry

J Li, J Ma, Q Li, L He, M Zhang, L Zheng… - Journal of Food …, 2023 - Wiley Online Library
A method was established for the determination of 18 flavonoids in tea by ultra‐performance
liquid chromatography coupled with quadrupole/time‐of‐flight mass spectrometry (UPLC‐Q …

Co-existing polysaccharides affect the systemic exposure of major bioactive ingredients in Chang-Kang-Fang, a multi-herb prescription for treatment of irritable bowel …

P Zhong, J Zhou, YT Fan, MF Guo, H Zhu… - Journal of …, 2022 - Elsevier
Abstract Ethnopharmacological relevance Chang-Kang-Fang (CKF) is a traditional Chinese
herbal formula used for treatment of irritable bowel syndrome (IBS) in China. Decoction is …

[HTML][HTML] Matrix-assisted laser desorption/ionization mass spectrometry for the rapid and high throughput analysis of betaine and trigonelline in Lycium chinense Mill …

P Zhou, D Chen, C Liu, L Liu, T Zheng, W Cheng… - Food Chemistry: X, 2024 - Elsevier
A rapid, simple, effective, and green method for the determination of betaine and trigonelline
from Lycium chinense Mill.(LCM) and the quantification of the trigonelline in coffee was …

[PDF][PDF] 大肠杆菌合成41: 基异亮> 酸的代谢工程研究

S No - China Brewing, 2023 - manu61.magtech.com.cn
为进# $ 提高大% 杆菌(Escherichia coli) 合成41E 基异亮氨酸的性能, 以前& 构'的重(菌株
Escherichia coli IEOH19 为) 发菌株进* 代谢" 程+,. 百-, 过表达./012 制3 用的45 氨酸6 …