In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is
incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Hemochromatosis | New England Journal of Medicine Skip to main content The New England
Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology Clinical …

Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron
supply for hemoglobin synthesis and essential metabolic functions, humans and other …

Iron is an essential element in biology, required for numerous cellular processes. Either too
much or too little iron can be detrimental, and organisms have developed mechanisms for …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

Hypoferremia is a common response to systemic infections or generalized inflammatory
disorders. In mouse models, the development of hypoferremia during inflammation requires …

BACKGROUND: Iron is utilized by several proteins as cofactor for major biological
processes. However, iron may also harm cells by catalyzing the generation of free radicals …