For many years, it was assumed that neurons and glia in the central nervous system were
produced from two distinct precursor pools that diverged early during embryonic …

▪ Abstract Widespread cell migrations are the hallmark of vertebrate brain development. In
the early embryo, morphogenetic movements of precursor cells establish the rhombomeres …

The developmental fates of subventricular zone (SVZ) cells of the postnatal rat forebrain
were determined by retroviral-mediated gene transfer and immunolabeling for glial antigens …

The cerebral cortex, occupying over 70 percent of our brain mass, is key to any
understanding of the workings--and disorders--of the human brain. offering a …

Cyclin-dependent kinase 5 (cdk5) is highly homologous to other members of the cdk family
that are known to function in proliferating cells. Despite the structural similarity, cdk5 …

NEUROECTODERM cells in the cortical ventricular zone generate many diverse cell types,
maintain the ventricular zone during embryonic life and create another germinal layer, the …

DNA methyltransferase I (Dnmt1), the maintenance enzyme for DNA cytosine methylation, is
expressed at high levels in the CNS during embryogenesis and after birth. Because …

The cerebral cortex of the mammalian brain has expanded rapidly during the course of
evolution and acquired structurally distinguishable areas devoted to separate functions. In …

Neurons in the mammalian neocortex are organized into functional columns,. Within a
column, highly specific synaptic connections are formed to ensure that similar physiological …

A fundamental feature of the mammalian neocortex is its columnar organization. In the visual
cortex, functional columns consisting of neurons with similar orientation preferences have …