Rhodococcus strains as a good biotool for neutralizing pharmaceutical pollutants and obtaining therapeutically valuable products: Through the past into the future

I Ivshina, G Bazhutin, E Tyumina - Frontiers in Microbiology, 2022 - frontiersin.org
Active pharmaceutical ingredients present a substantial risk when they reach the
environment and drinking water sources. As a new type of dangerous pollutants with high …

Stairway to Stereoisomers: Engineering Short‐and Medium‐Chain Ketoreductases To Produce Chiral Alcohols

AP Shanbhag - ChemBioChem, 2023 - Wiley Online Library
The short‐and medium‐chain dehydrogenase/reductase superfamilies are responsible for
most chiral alcohol production in laboratories and industries. In nature, they participate in …

Substrate selectivity and kinetic studies of (S)-specific alcohol dehydrogenase purified from Candida parapsilosis ATCC 7330

J Pinto, A Chadha, SN Gummadi - Biocatalysis and Agricultural …, 2022 - Elsevier
Biocatalytic reduction catalysed by alcohol dehydrogenases is a valuable tool for
asymmetric synthesis of chiral alcohols. This study reports the broad substrate specificity of …

Enhancing the activity of a monomeric alcohol dehydrogenase for site-specific applications by site-directed mutagenesis

A Essert, K Castiglione - Protein Engineering, Design and …, 2023 - academic.oup.com
Gene fusion or co-immobilization are key tools to optimize enzymatic reaction cascades by
modulating catalytic features, stability and applicability. Achieving a defined spatial …

Using a novel data-driven combinatorial mutagenesis strategy to engineer an alcohol dehydrogenase for efficient geraniol synthesis

Y Zheng, B Zhang, Y Xie, J Lin, D Wei - Biochemical Engineering Journal, 2022 - Elsevier
The monoterpene geraniol is widely applied in perfume, food, pharmaceutical, and other
industries. However, conventional methods of geraniol production, including chemical …

Efficient Chemoenzymatic Cascade Reaction for One-Pot Enantioselective Synthesis of Chiral Indole Derivatives in Water

XT Zhao, WD Li, Y Yao, ML Shi, YJ Wei, RD Lin… - Available at SSRN … - papers.ssrn.com
One-pot chemoenzymatic cascade process integrating the merits of biocatalysis and
chemical catalysis has become a promising method for the efficient synthesis of complex …