Pancreatic cancer surveillance and survival of high-risk individuals

AL Blackford, MI Canto, M Dbouk, RH Hruban… - JAMA …, 2024 - jamanetwork.com
Importance Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with increasing
incidence. The majority of PDACs are incurable at presentation, but population-based …

Precursor lesions in familial and hereditary pancreatic cancer

MJ Pflüger, LAA Brosens, RH Hruban - Familial Cancer, 2024 - Springer
Infiltrating ductal adenocarcinoma of the pancreas, referred to here as “pancreatic cancer,” is
one of the deadliest of all of the solid malignancies. The five-year survival rate in the United …

Automated artificial intelligence model trained on a large data set can detect pancreas cancer on diagnostic computed tomography scans as well as visually occult …

P Korfiatis, G Suman, NG Patnam, KH Trivedi… - Gastroenterology, 2023 - Elsevier
Background & Aims The aims of our case-control study were (1) to develop an automated 3-
dimensional (3D) Convolutional Neural Network (CNN) for detection of pancreatic ductal …

[HTML][HTML] A rigorous multi-laboratory study of known PDAC biomarkers identifies increased sensitivity and specificity over CA19-9 alone

B Haab, L Qian, B Staal, M Jain, J Fahrmann… - Cancer Letters, 2024 - Elsevier
A blood test that enables surveillance for early-stage pancreatic ductal adenocarcinoma
(PDAC) is an urgent need. Independent laboratories have reported PDAC biomarkers that …

Early detection of pancreatic cancer in the era of precision medicine

TM Ahmed, S Kawamoto, F Lopez-Ramirez… - Abdominal …, 2024 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related
mortality and it is often diagnosed at advanced stages due to non-specific clinical …

Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings

AL Kiemen, PH Wu, AM Braxton, TC Cornish… - Science …, 2024 - science.org
Pancreatic ductal adenocarcinoma is a rare but lethal cancer. Recent evidence suggests
that pancreatic intraepithelial neoplasia (PanIN), a microscopic precursor lesion that gives …

Temporal Trends in Body Composition and Metabolic Markers Prior to Diagnosis of Pancreatic Ductal Adenocarcinoma

DCF Klatte, A Weston, Y Ma, H Sledge, A Bali… - Clinical …, 2024 - Elsevier
Background & Aims Changes in body composition and metabolic factors may serve as
biomarkers for the early detection of pancreatic ductal adenocarcinoma (PDAC). The aim of …

Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression

Y Wang, TSM Lih, JW Lee, T Ohtsuka, Y Hozaka… - bioRxiv, 2024 - biorxiv.org
In order to advance our understanding of precancers in the pancreas, 69 pancreatic
intraductal papillary neoplasms (IPNs), including 64 intraductal papillary mucinous …

Detection and characterization of pancreatic lesion with artificial intelligence: The SFR 2023 artificial intelligence data challenge

T Aouad, V Laurent, P Levant, A Rode… - Diagnostic and …, 2024 - Elsevier
Purpose The purpose of the 2023 SFR data challenge was to invite researchers to develop
artificial intelligence (AI) models to identify the presence of a pancreatic mass and …

Advancements in Pancreatic Cancer Treatment: A Comprehensive Review of Current Therapies and Future Directions

WM Stec, Z Kudas, M Górka, A Wojtkiewicz… - Quality in Sport, 2024 - apcz.umk.pl
Pancreatic cancer still has a 5-year survival rate in the single digits, making it one of the
most aggressive and deadly cancers. The therapy of pancreatic cancer presents …