The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Abstract Poly (ADP-ribose) polymerases (PARPs) are involved in the regulation of many
cellular functions. Three consequences of the activation of PARP1, which is the main isoform …

Myosin is a molecular motor, which interacts with actin to convert the energy from ATP
hydrolysis into mechanical work. In cardiac myocytes, two myosin isoforms are expressed …

The term ischemia-reperfusion injury describes the experimentally and clinically prevalent
finding that tissue ischemia with inadequate oxygen supply followed by successful …

Dysregulation of nitric oxide (NO) and increased oxidative and nitrosative stress are
implicated in the pathogenesis of heart failure. Peroxynitrite is a reactive oxidant that is …

Reperfusion injury (RI), a potential life-threatening disorder, represents an acute
inflammatory response after periods of ischemia resulting from myocardial infarction, stroke …

Heart failure is the major cause of hospitalization, morbidity and mortality worldwide.
Previous experimental and clinical studies have suggested that there is an increased …

Recent evidence indicates that peroxynitrite represents a major cytotoxic effector in heart
diseases, but its mechanisms of action are still not known exactly. Notably, the ability of …

Objective: Sepsis is associated with increased production of superoxide and nitric oxide,
with consequent peroxynitrite generation. Cardiodepression is induced in the heart during …