The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

Microglia, the resident immune cells of the brain and retina, are constantly engaged in the
surveillance of their surrounding neural tissue. During embryonic development they infiltrate …

Retinal degenerative diseases are major causes of vision loss and blindness worldwide and
are characterized by chronic and progressive neuronal loss. One common feature of retinal …

Glaucoma is an ocular disorder characterized by the progressive loss of retinal ganglion
cells (RGC) and their axons. There are various hypotheses concerning the cause of RGC …

Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …

Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …

Background: Y-27632 is a potent ophthalmic drug for the treatment of ocular hypertension, a
globally prevalent eye disease. However, the sustained delivery of Y-27632 by a therapeutic …

Most irreversible blindness observed with glaucoma and retina-related ocular diseases,
including age-related macular degeneration and diabetic retinopathy, have their origin in the …

Inherited retinal dystrophies (IRDs) are a group of retinal disorders that cause progressive
and severe loss of vision because of retinal cell death, mainly photoreceptor cells. IRDs …

Purpose: This review represents the current in vitro, in vivo animal and human researches
on the roles of IL-6 in inflammatory ocular disorders. Data sources were literature reviewed …