Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer
DD Bowtell, S Böhm, AA Ahmed, PJ Aspuria… - Nature reviews …, 2015 - nature.com
High-grade serous ovarian cancer (HGSOC) accounts for 70–80% of ovarian cancer deaths,
and overall survival has not changed significantly for several decades. In this Opinion article …
and overall survival has not changed significantly for several decades. In this Opinion article …
“Platinum resistant” ovarian cancer: what is it, who to treat and how to measure benefit?
Abstract “Platinum resistant” ovarian cancer was historically defined as disease recurrence
within 6 months of completion of first-line platinum-based chemotherapy, although this is …
within 6 months of completion of first-line platinum-based chemotherapy, although this is …
Genetic/familial high-risk assessment: breast, ovarian, and pancreatic, version 2.2021, NCCN clinical practice guidelines in oncology
MB Daly, T Pal, MP Berry, SS Buys, P Dickson… - Journal of the National …, 2021 - jnccn.org
The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …
Pancreatic focus primarily on assessment of pathogenic or likely pathogenic variants …
Inherited mutations in women with ovarian carcinoma
Importance Germline mutations inBRCA1andBRCA2are relatively common in women with
ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime …
ovarian, fallopian tube, and peritoneal carcinoma (OC) causing a greatly increased lifetime …
Outcomes from opportunistic salpingectomy for ovarian cancer prevention
Importance Opportunistic salpingectomy (OS), which is the removal of fallopian tubes during
hysterectomy or instead of tubal ligation without removal of ovaries, is recommended to …
hysterectomy or instead of tubal ligation without removal of ovaries, is recommended to …
Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas
KP Pennington, T Walsh, MI Harrell, MK Lee… - Clinical Cancer …, 2014 - AACR
Purpose: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …
Poor interobserver reproducibility in the diagnosis of high-grade endometrial carcinoma
CB Gilks, E Oliva, RA Soslow - The American journal of surgical …, 2013 - journals.lww.com
Patients with high-grade subtypes of endometrial carcinoma (grade 3 endometrioid, serous,
clear cell, or carcinosarcoma) have a relatively poor prognosis. The specific subtype may be …
clear cell, or carcinosarcoma) have a relatively poor prognosis. The specific subtype may be …
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer
We performed phylogenetic analysis of high-grade serous ovarian cancers (68 samples
from seven patients), identifying constituent clones and quantifying their relative …
from seven patients), identifying constituent clones and quantifying their relative …
Tumor evolution and chemoresistance in ovarian cancer
Abstract Development of novel strategies to overcome chemoresistance is central goal in
ovarian cancer research. Natural history of the cancer development and progression is …
ovarian cancer research. Natural history of the cancer development and progression is …
Implementing rapid, robust, cost-effective, patient-centred, routine genetic testing in ovarian cancer patients
A George, D Riddell, S Seal, S Talukdar… - Scientific reports, 2016 - nature.com
Advances in DNA sequencing have made genetic testing fast and affordable, but limitations
of testing processes are impeding realisation of patient benefits. Ovarian cancer exemplifies …
of testing processes are impeding realisation of patient benefits. Ovarian cancer exemplifies …