Nanocarriers for ocular drug delivery: Current status and translational opportunity

S Gorantla, VK Rapalli, T Waghule, PP Singh… - RSC …, 2020 - pubs.rsc.org
Ocular diseases have a significant effect on vision and quality of life. Drug delivery to ocular
tissues is a challenge to formulation scientists. The major barriers to delivering drugs to the …

Optimization of nanostructured lipid carriers: Understanding the types, designs, and parameters in the process of formulations

B Subramaniam, ZH Siddik, NH Nagoor - Journal of nanoparticle research, 2020 - Springer
Lipid-based nanoparticles for drug delivery have been employed in the development of
nanomedicine for various applications. One such versatile nanoparticle type is …

Lipid nanoparticles for the posterior eye segment

L Bonilla, M Espina, P Severino, A Cano, M Ettcheto… - Pharmaceutics, 2021 - mdpi.com
This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles,
Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for …

Development and optimization of imiquimod-loaded nanostructured lipid carriers using a hybrid design of experiments approach

S Kim, S Abdella, F Abid, F Afinjuomo… - International Journal …, 2023 - Taylor & Francis
Background Imiquimod (IMQ) is an immunomodulating drug that is approved for the
treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and …

Lipid-based nanocarriers for ophthalmic administration: towards experimental design implementation

FM González-Fernández, A Bianchera, P Gasco… - Pharmaceutics, 2021 - mdpi.com
Nanotherapeutics based on biocompatible lipid matrices allow for enhanced solubility of
poorly soluble compounds in the treatment of ophthalmic diseases, overcoming the …

Lipid-based nanocarriers for ocular drug delivery: An updated review

B Das, AK Nayak, S Mallick - Journal of Drug Delivery Science and …, 2022 - Elsevier
Recent years have witnessed a boom in ocular nanomedicine research with a number of
lipid-based nanocarriers such as liposomes, niosomes, cubosomes, nanoemulsions, solid …

Understanding the impact of multi-factorial composition on efficient loading of the stable ketoprofen nanoparticles on orodispersible films using Box-Behnken Design

HG Shah, V Rathod, P Basim, B Gajera… - Journal of Pharmaceutical …, 2022 - Elsevier
The purpose of the present study was to prepare Orodispersible films (ODFs) loaded with
ketoprofen nanoparticles (KT-NP). The Box-Behnken design was constructed in developing …

Combinatorial delivery of Ribociclib and green tea extract mediated nanostructured lipid carrier for oral delivery for the treatment of breast cancer synchronising in silico, in vitro …

A Sartaj, Annu, M Alam, L Biswas, MS Yar… - Journal of Drug …, 2022 - Taylor & Francis
Purpose The current research investigated the development and evaluation of dual drug-
loaded nanostructure lipidic carriers (NLCs) of green tea extract and Ribociclib. Method In …

Loteprednol-loaded nanoformulations for corneal delivery by quality-by-design concepts: optimization, characterization, and anti-inflammatory activity

B Uner, S Ozdemir, C Tas, M Uner, Y Ozsoy - AAPS PharmSciTech, 2023 - Springer
Loteprednol etabonate (LE) is a topical corticosteroid that uses inflammatory conditions of
the eye. It has a low ocular bioavailability and side effects such as corneal disorder, eye …

Emu oil enriched nanostructured lipid carriers of lornoxicam burdened polymeric gel augmented drug delivery and assisted cartilage repairing in knee osteoarthritis: In …

A Bhosale, VGSS Jyothi, P Devangan, G Bajad… - Journal of Drug Delivery …, 2024 - Elsevier
Lornoxicam (LRX) alleviates pain and inflammation associated with knee osteoarthritis
(OAS). However, inadequate solubility, short half-life, and gastrointestinal side-effects on …