Increasing age alters innate immune–mediated responses; however, the mechanisms
underpinning these changes in humans are not fully understood. Using a human dermal …

T‑cell/transmembrane immunoglobulin and mucin domain containing 4 (TIM‑4) is a
phosphatidylserine receptor that is mainly expressed on antigen‑presenting cells and is …

The safety and efficacy of several life-saving therapeutic proteins are compromised due to
their immunogenicity. Once a sustained immune response against a protein-based therapy …

Induction and regulation of specific intestinal immunoglobulin (Ig) A responses critically
depend on dendritic cell (DC) subsets and the T cells they activate in the Peyer's patches …

Autoimmune conditions, allergies, and immunogenicity against therapeutic proteins are
initiated by the unwanted immune response against self and non-self proteins. The …

Increased T-regulatory cell activity drives tumor progression in the compound
APCmin/+/enterotoxic Bacteroides fragilis colon cancer model. At the same time, how …

Phosphatidylserine (PS) is an anionic phospholipid exposed on the surface of apoptotic
cells. The exposure of PS typically recruits and signals phagocytes to engulf and silently …

T‐cell immunoglobulin (Ig) and mucin domain‐containing 1 (Tim‐1) and Tim‐4 are two
members of the Tim family. In mammals, Tim‐1 and Tim‐4 are proteins mainly expressed in …

Immunogenicity is a concern that has undermined the development, safety, and efficacy of
many lifesaving therapies. During treatment of Pompe Disease, nearly 100% of patients …