Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Accumulating evidence demonstrates important roles for metabolism in cell fate
determination. However, it is a challenge to assess metabolism at a spatial resolution that …

Current metabolomics and lipidomics studies are limited in the number of examined
matrices, the breadth and scope of methods, reporting the number of metabolites, and data …

Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Label-free molecular imaging techniques such as matrix-assisted laser desorption ionization
mass spectrometry imaging (MALDI-MSI) enable the direct and simultaneous mapping of …

Tumors are comprised of a multitude of cell types spanning different microenvironments.
Mass spectrometry imaging (MSI) has the potential to identify metabolic patterns within the …

Spatial metabolomics has matured and is driving innovation in mass spectrometry,
metabolomics and spatial omics. With exciting discoveries, complementary capabilities and …

Mass spectrometry imaging (MSI) is an emerging technology in cancer metabolomics.
Desorption electrospray ionization (DESI) and matrix-assisted laser desorption ionization …

Neuronal activity creates an intense energy demand that must be met by rapid metabolic
responses. To investigate metabolic adaptations in the neuron-enriched dentate granule cell …