Anticancer drugs: recent strategies to improve stability profile, pharmacokinetic and pharmacodynamic properties
G Ioele, M Chieffallo, MA Occhiuzzi, M De Luca… - Molecules, 2022 - mdpi.com
In past decades, anticancer research has led to remarkable results despite many of the
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …
approved drugs still being characterized by high systemic toxicity mainly due to the lack of …
Preparation, characterization and in vitro anticancer performance of nanoconjugate based on carbon quantum dots and 5-Fluorouracil
This study is focused on the development of a nanodevice for loading and release of 5-
Fluorouracil (5-FU) with a view to improving its therapeutic efficiency, using as strategy the …
Fluorouracil (5-FU) with a view to improving its therapeutic efficiency, using as strategy the …
Acute aquatic toxicity assessment of six anti-cancer drugs and one metabolite using biotest battery–biological effects and stability under test conditions
Available ecotoxicological data for anti-cancer drugs and their metabolites are incomplete,
and only some studies have been accompanied by chemical analysis. Therefore, the main …
and only some studies have been accompanied by chemical analysis. Therefore, the main …
New insights about the intercalation of 5-Fluorouracil into 2D Mg–Al layered double hydroxide nanosheets: A theoretical and experimental investigation
EHC Silva, ESM Cutrim, MRC Iemma, HS Barud… - Journal of Drug Delivery …, 2023 - Elsevier
Layered double hydroxides (LDH) are interesting 2D inorganic platforms for biomedical
purposes. In contrast to previous studies, this work reports the intercalation of 5-Fluorouracil …
purposes. In contrast to previous studies, this work reports the intercalation of 5-Fluorouracil …
Hydrolytic pathway of 5-fluorouracil in aqueous solutions for clinical use
R Legay, S Massou, J Azéma, R Martino… - … of Pharmaceutical and …, 2014 - Elsevier
The purpose of the study was to investigate the degradation pathway of 5-fluorouracil (FU) in
the situation of commercial formulations for clinical use, namely FU dissolved in sodium …
the situation of commercial formulations for clinical use, namely FU dissolved in sodium …
Hydrolytic stability of anticancer drugs and one metabolite in the aquatic environment
M Toński, J Dołżonek, P Stepnowski… - … Science and Pollution …, 2021 - Springer
Due to the genotoxic, carcinogenic and teratogenic mechanism of action, anticancer drugs
are highly hazardous compounds. Their occurrence, fate, and effects in the environment …
are highly hazardous compounds. Their occurrence, fate, and effects in the environment …
Solvent effect on the photolysis of 5‐fluorouracil: A kinetic study
A Khurshid, I Ahmad, N Khan… - … Journal of Chemical …, 2023 - Wiley Online Library
A photodegradation study of 5‐fluorouracil (5‐FU) has been carried out in the water (pH 7.0)
and organic solvents (chloroform, ethyl acetate, acetone, 1‐butanol, 1‐propanol, ethanol …
and organic solvents (chloroform, ethyl acetate, acetone, 1‐butanol, 1‐propanol, ethanol …
Preparation and Characterization of Four Major Novel Degradation Products of Pralatrexate Injection and Validation of HPLC-UV Method
RVR Prabhakara Sastry, CS Venkatesan… - Current …, 2019 - ingentaconnect.com
Background: Four major degradation products (1-4) of pralatrexate injection were formed
under hydrolytic and light stress conditions. The impurities 1 and 2 were the potential photo …
under hydrolytic and light stress conditions. The impurities 1 and 2 were the potential photo …