In an era of rapid technological development and evolving diagnostic possibilities, the
electrocardiogram (ECG) is living an authentic “renaissance” in myocardial diseases. To …

To date, no compounds or interventions exist that treat or prevent sarcomeric
cardiomyopathies. Established therapies currently improve the outcome, but novel therapies …

Background—Hypertrophic cardiomyopathy (HCM), the most common mendelian heart
disorder, remains an orphan of disease-specific pharmacological treatment because of the …

Hypertrophic cardiomyopathy (HCM) is a cardiac genetic disease accompanied by structural
and contractile alterations. We identified a rare c. 740C> T (p. T247M) mutation in ACTN 2 …

Background: Mild hypertrophy but increased arrhythmic risk characterizes the stereotypic
phenotype proposed for hypertrophic cardiomyopathy (HCM) caused by thin-filament …

Hypertrophic cardiomyopathy (HCM) is the most common mendelian heart disease, with a
prevalence of 1/500. HCM is a primary cause of sudden death, due to an heightened risk of …

Hypertrophic cardiomyopathy (HCM) is a common inherited monogenic disease with a
prevalence of 1/500 in the general population, representing an important cause of …

Background: Aberrant calcium signaling may contribute to arrhythmias and adverse
remodeling in hypertrophic cardiomyopathy (HCM). Mutations in sarcomere genes may …

Background Pseudonormal T waves may be detected on stress electrocardiograms (ECGs)
in hypertrophic cardiomyopathy (HCM). Either myocardial ischaemia or purely exercise …

Background—A portion of sudden cardiac deaths can be attributed to structural heart
diseases, such as hypertrophic cardiomyopathy (HCM) or cardiac channelopathies such as …