Complex regulatory landscapes control the pleiotropic transcriptional activities of
developmental genes. For most genes, the number, location, and dynamics of their …

Transcription factor (TF)-mediated reprogramming to pluripotency is a slow and inefficient
process, because most pluripotency TFs fail to access relevant target sites in a refractory …

The maintenance of pluripotency in mouse embryonic stem cells (ESCs) is governed by the
action of an interconnected network of transcription factors. Among them, only Oct4 and …

Early embryogenesis is driven by transcription factors (TFs) that first activate the zygotic
genome and then specify the lineages constituting the blastocyst. Although the TFs …

Accumulation of topological stress in the form of DNA supercoiling is inherent to the advance
of RNA polymerase II (Pol II) and needs to be resolved by DNA topoisomerases to sustain …

The impact of LMO 2 expression on cell lineage decisions during T‐cell leukemogenesis
remains largely elusive. Using genetic lineage tracing, we have explored the potential of …

We present the software Condition-specific Regulatory Units Prediction (CRUP) to infer from
epigenetic marks a list of regulatory units consisting of dynamically changing enhancers with …

Motivation Automated chromatin segmentation based on ChIP-seq (chromatin
immunoprecipitation followed by sequencing) data reveals insights into the epigenetic …

Enhancers are important regulatory regions located throughout the genome, primarily in non-
coding regions. Several experimental methods have been developed over the last several …

Epigenomics, the study of the human genome and its interactions with proteins and other
cellular elements, has become of significant interest in the past decade. Several landmark …