Steviol glycosides are a group of highly sweet diterpene glycosides discovered in only a few
plant species, most notably the Paraguayan shrub Stevia rebaudiana. During the past few …

Isoprenoids are a class of natural products with more than 55,000 members. All isoprenoids
are constructed from two precursors, isopentenyl diphosphate and its isomer dimethylallyl …

Although alkyl complexes of [Fe4S4] clusters have been invoked as intermediates in a
number of enzymatic reactions, obtaining a detailed understanding of their reactivity patterns …

Reported herein are alkyne and alkene adducts of synthetic [Fe4S4]+ clusters that model
intermediates and inhibitor-bound states in enzymes involved in isoprenoid biosynthesis …

Understanding the mechanisms through which persistent organic pollutants (POPs) form
during combustion processes is critical for controlling emissions of POPs, but the …

Alkyl-ligated iron–sulfur clusters in the [Fe4S4] 3+ charge state have been proposed as short-
lived intermediates in a number of enzymatic reactions. To better understand the properties …

Enzymes of the methylerythritol phosphate pathway of isoprenoid biosynthesis are attractive
anti‐infective drug targets. The last two enzymes of this pathway, IspG and IspH, are [Fe4S4] …

The advanced electron paramagnetic resonance (EPR) techniques, electron nuclear double
resonance (ENDOR) and electron spin echo envelope modulation (ESEEM) spectroscopies …

(E)-4-Hydroxy-3-methylbut-2-enyl diphosphate reductase, or IspH (formerly known as LytB),
catalyzes the terminal step of the bacterial methylerythritol phosphate (MEP) pathway for …

The [4Fe–4S] protein IspH in the methylerythritol phosphate isoprenoid biosynthesis
pathway is an important anti-infective drug target, but its mechanism of action is still the …