The endothelial angiopoietin (ANG)–TIE growth factor receptor pathway regulates vascular
permeability and pathological vascular remodelling during inflammation, tumour …

Pulmonary hypertension (PH) is a progressive disease that arises from multiple etiologies
and ultimately leads to right heart failure as the predominant cause of morbidity and …

Plasma levels of angiopoietin-2 are increased in patients with chronic kidney disease
(CKD). Moreover, mouse models of progressive kidney disease also demonstrate increased …

Systemic inflammation is a hallmark of commonly encountered diseases ranging from
bacterial sepsis to sterile syndromes such as major trauma. Derangements in the host …

Aims Monocytes are central for atherosclerotic vascular inflammation. The human non-
classical, patrolling subtype, which expresses high levels of CD16 and fractalkine receptor …

Attraction, retention, and differentiation of leukocytes to and within the kidney are governed
by chemokines. The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1 are …

Background Several protein-bound uraemic toxins (PBUTs) have been associated with
cardiovascular (CV) and all-cause mortality in chronic kidney disease (CKD) but the degree …

Objectives: Angiopoietins modulate endothelial permeability via endothelial cell junctions.
Angiopoietin-2 blocks the angiopoietin-1/Tie-2 interaction that stabilizes these junctions, and …

Diabetic nephropathy is the main cause of end-stage renal failure in the Western world. In
diabetes, metabolic and haemodynamic perturbations disrupt the integrity of the glomerular …

Arterial stiffness is typical feature of vascular remodeling in chronic kidney disease (CKD).
Increased arterial stiffness raises flow and pressure pulsatility and is considered the …