Neuroimaging biomarkers in schizophrenia
NV Kraguljac, WM McDonald… - American Journal of …, 2021 - Am Psychiatric Assoc
Schizophrenia is a complex neuropsychiatric syndrome with a heterogeneous genetic,
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
neurobiological, and phenotypic profile. Currently, no objective biological measures—that is …
Glutamatergic and GABAergic metabolite levels in schizophrenia-spectrum disorders: a meta-analysis of 1H-magnetic resonance spectroscopy studies
Abstract Background The glutamate (Glu) and gamma aminobutyric acid (GABA)
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
hypotheses of schizophrenia were proposed in the 1980s. However, current findings on …
Nature of glutamate alterations in schizophrenia: a meta-analysis of proton magnetic resonance spectroscopy studies
K Merritt, A Egerton, MJ Kempton, MJ Taylor… - JAMA …, 2016 - jamanetwork.com
Importance Alterations in glutamatergic neurotransmission may be fundamental to the
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …
pathophysiology of schizophrenia, and the glutamatergic system is a target for novel …
EPA guidance on the early intervention in clinical high risk states of psychoses
SJ Schmidt, F Schultze-Lutter… - European …, 2015 - cambridge.org
This guidance paper from the European Psychiatric Association (EPA) aims to provide
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …
evidence-based recommendations on early intervention in clinical high risk (CHR) states of …
Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level: a mega …
Importance Proton magnetic resonance spectroscopy (1H-MRS) studies indicate that altered
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
brain glutamatergic function may be associated with the pathophysiology of schizophrenia …
The role of the thalamus in schizophrenia from a neuroimaging perspective
The thalamus is a crucial node for brain physiology and part of functional and structural
pathways relevant for schizophrenia. Relatively few imaging studies on schizophrenia have …
pathways relevant for schizophrenia. Relatively few imaging studies on schizophrenia have …
Response to initial antipsychotic treatment in first episode psychosis is related to anterior cingulate glutamate levels: a multicentre 1H-MRS study (OPTiMiSE)
Conventional antipsychotic medication is ineffective in around a third of patients with
schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated …
schizophrenia, and the nature of the therapeutic response is unpredictable. We investigated …
The effect of a high-dose vitamin B multivitamin supplement on the relationship between brain metabolism and blood biomarkers of oxidative stress: a randomized …
A diet rich in B-group vitamins is essential for optimal body and brain function, and
insufficient amounts of such vitamins have been associated with higher levels of neural …
insufficient amounts of such vitamins have been associated with higher levels of neural …
Translating the MAM model of psychosis to humans
Elevated dopamine function and alterations in medial temporal lobe (MTL) structure and
function are two of the most robust findings in schizophrenia, but how interactions between …
function are two of the most robust findings in schizophrenia, but how interactions between …
Structural and functional imaging markers for susceptibility to psychosis
C Andreou, S Borgwardt - Molecular psychiatry, 2020 - nature.com
The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …