The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of systemic
autoimmune diseases that affect the skeletal muscles and can also involve the skin, joints …

Background Obesity and related metabolic disturbances including diabetes, hypertension
and hyperlipidemia predict future cognitive decline. Asia has a high prevalence of both …

Early-onset systemic lupus erythematosus presents with a more severe disease and is
associated with a greater genetic burden, especially in patients from Black, Asian or …

Arabic populations are underrepresented in large genome projects; therefore, the frequency
of clinically actionable variants among Arabs is largely unknown. Here, we investigated …

Chronic inflammation is a hallmark of age-related disease states. The effectiveness of
inflammatory proteins including C-reactive protein (CRP) in assessing long-term …

Background Type 2 diabetes, cardiovascular disease, and related cardiometabolic
disturbances are increasing rapidly in the Asia-Pacific region. We investigated the …

Structural variants (SVs) are significant contributors to inter-individual genetic variation
associated with traits and diseases. Current SV studies using whole-genome sequencing …

Abstract Rare genetic diseases affect 5–8% of the population but are often undiagnosed or
misdiagnosed. Electronic health records (EHR) contain large amounts of data, which …

Genetic neuromuscular diseases are clinically and genetically heterogeneous genetic
disorders that primarily affect the peripheral nerves, muscles, and neuromuscular junctions …

One sixth of human cancers harbor pathogenic germline variants, but few studies have
established their functional contribution to cancer outcomes. Here, we developed a …