Innovations to culturing the uncultured microbial majority

WH Lewis, G Tahon, P Geesink, DZ Sousa… - Nature Reviews …, 2021 - nature.com
Despite the surge of microbial genome data, experimental testing is important to confirm
inferences about the cell biology, ecological roles and evolution of microorganisms. As the …

The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

C Milani, S Duranti, F Bottacini, E Casey… - Microbiology and …, 2017 - Am Soc Microbiol
The human gut microbiota is engaged in multiple interactions affecting host health during
the host's entire life span. Microbes colonize the neonatal gut immediately following birth …

The integrative human microbiome project

HMP Integrative, LM Proctor, HH Creasy… - …, 2019 - ui.adsabs.harvard.edu
Abstract The NIH Human Microbiome Project (HMP) has been carried out over ten years and
two phases to provide resources, methods, and discoveries that link interactions between …

GABA-modulating bacteria of the human gut microbiota

P Strandwitz, KH Kim, D Terekhova, JK Liu… - Nature …, 2019 - nature.com
The gut microbiota affects many important host functions, including the immune response
and the nervous system. However, while substantial progress has been made in growing …

New insights from uncultivated genomes of the global human gut microbiome

S Nayfach, ZJ Shi, R Seshadri, KS Pollard… - Nature, 2019 - nature.com
The genome sequences of many species of the human gut microbiome remain unknown,
largely owing to challenges in cultivating microorganisms under laboratory conditions. Here …

Human gut microbiome: function matters

A Heintz-Buschart, P Wilmes - Trends in microbiology, 2018 - cell.com
The human gut microbiome represents a complex ecosystem contributing essential
functions to its host. Recent large-scale metagenomic studies have provided insights into its …

A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research

M Poyet, M Groussin, SM Gibbons, J Avila-Pacheco… - Nature medicine, 2019 - nature.com
Our understanding of how the gut microbiome interacts with its human host has been
restrained by limited access to longitudinal datasets to examine stability and dynamics, and …

Culturing of 'unculturable'human microbiota reveals novel taxa and extensive sporulation

HP Browne, SC Forster, BO Anonye, N Kumar… - Nature, 2016 - nature.com
Our intestinal microbiota harbours a diverse bacterial community required for our health,
sustenance and wellbeing,. Intestinal colonization begins at birth and climaxes with the …

New insights into human nostril microbiome from the expanded human oral microbiome database (eHOMD): a resource for the microbiome of the human …

IF Escapa, T Chen, Y Huang, P Gajare, FE Dewhirst… - Msystems, 2018 - Am Soc Microbiol
ABSTRACT The expanded Human Oral Microbiome Database (eHOMD) is a
comprehensive microbiome database for sites along the human aerodigestive tract that …

An integrated catalog of reference genes in the human gut microbiome

J Li, H Jia, X Cai, H Zhong, Q Feng, S Sunagawa… - Nature …, 2014 - nature.com
Many analyses of the human gut microbiome depend on a catalog of reference genes.
Existing catalogs for the human gut microbiome are based on samples from single cohorts …